亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
粉色视频在线观看完整版高清免费,韩日AV无码片一区二区三区,18视频入口网站在线看
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-IGF1R/Gold Conjugated antibody (bs-0227R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0227R-Gold
英文名稱 Rabbit Anti-IGF1R/Gold Conjugated antibody
中文名稱 膠體金標記的胰島素樣生長因子I受體抗體
別    名 CD221; CD221 antigen; IGF1 Receptor; IGF 1 receptor; IGF 1R; IGF I receptor; IGF1R; IGFIR; IGFIRC; Insulin like growth factor 1 receptor; Insulin like growth factor 1 receptor precursor; JTK13; MGC142170; MGC142172; IGF1R_HUMAN; Insulin-like growth factor 1 receptor beta chain; IGF 1 receptor; IGF-1R; IGF I receptor; IGF-I receptor; IGF-IR.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 腫瘤  免疫學  信號轉(zhuǎn)導  生長因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  細胞膜受體  糖尿病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Dog,  (predicted: Rat, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 78/150kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IGF-1R alpha chain
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008].

Function:
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

Subunit:
Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Forms a hybrid receptor with INSR, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with ARRB1 and ARRB2.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibrobasts, spleen and placenta (at protein level). Expressed in a variety of tissues.

Post-translational modifications:
The cytoplasmic domain of the beta subunit is autophosphorylated on tyrosine residues in response to insulin-like growth factor I (IGF I).
Phosphorylation of Tyr-980 is required for IRS1- and SHC1-binding.

DISEASE:
Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance) [MIM:270450]. IGF1 resistance is a gowth deficiency disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Contains 3 fibronectin type-III domains.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 3480 Human

Entrez Gene: 16001 Mouse

Entrez Gene: 25718 Rat

Omim: 147370 Human

SwissProt: P08069 Human

SwissProt: Q60751 Mouse

SwissProt: P24062 Rat

Unigene: 643120 Human

Unigene: 714012 Human

Unigene: 275742 Mouse

Unigene: 10957 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
18禁美女裸体网站免费扒内衣 | 好吊视频一区二区三区 | 推油少妇久久99久久99久久 | 久久se精品一区精品二区 | **毛片免费观看 | 免费黄色网站在线观看 | 亚洲国产精品成人综合色GIF | 欧美日韩亚洲一区二区三区在线观看 | 绿意盎然侄子小钢炮的成长经历 | 久久综合久久自在自线精品自 | 色欲精品人妻AV一区二区三区 | 超级最爽的乱淫片免费 | 国产精品三P一区二区视频 最近高清中文字幕免费MV | 国产熟女内射OOOO | 亚洲中文字幕乱码免费播放 | 四川少妇BBB凸凸凸BBB | fuli.su黑料正能量入口 | 亚洲AV怡红院影院怡春院 | 污视频在线免费观看网站 | 欧美日韩亚洲精品国产色 | 国产一区二区高清 | 久久久这里只有免费精品2018 | 亚洲午夜尤物中文字幕在线 | 爱呦视频在线播放网址 | 久久国内免费视频 | 亚洲欧洲自拍偷拍 | 国产乱老熟视频乱老熟女51 | 美女内射视频WWW网站午夜 | 消息称久青青国产高清视频 | 欧美成人免费全部观看国产 | 成人小视频在线观看 | 国产日韩亚洲VA无码自线免费看不卡 | 性猛交xxxx乱大交孕妇 | 日韩美女做暖暖免费视频 | 蜜桃视频极品免费观看 | 国产人妖XXXX做受视频 | 国产精品久久久久久福利 | 亚洲韩欧美第25集完整版 | 日本BBW丰满牲交片 国产精品国产三级国产AV剧情 | 日韩欧美一区二区三区在线 | 国产在线观看免费观看不卡 |