亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产精品亚洲AV色欲在线观看,成年人在线免费网站
Rabbit Anti-IGF1R/BF488 Conjugated antibody (bs-0227R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0227R-BF488
英文名稱 Rabbit Anti-IGF1R/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的胰島素樣生長因子I受體抗體
別    名 CD221; CD221 antigen; IGF1 Receptor; IGF 1 receptor; IGF 1R; IGF I receptor; IGF1R; IGFIR; IGFIRC; Insulin like growth factor 1 receptor; Insulin like growth factor 1 receptor precursor; JTK13; MGC142170; MGC142172; IGF1R_HUMAN; Insulin-like growth factor 1 receptor beta chain; IGF 1 receptor; IGF-1R; IGF I receptor; IGF-I receptor; IGF-IR.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  生長因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  細(xì)胞膜受體  糖尿病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Dog,  (predicted: Rat, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 78/150kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IGF-1R alpha chain
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008].

Function:
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

Subunit:
Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Forms a hybrid receptor with INSR, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with ARRB1 and ARRB2.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibrobasts, spleen and placenta (at protein level). Expressed in a variety of tissues.

Post-translational modifications:
The cytoplasmic domain of the beta subunit is autophosphorylated on tyrosine residues in response to insulin-like growth factor I (IGF I).
Phosphorylation of Tyr-980 is required for IRS1- and SHC1-binding.

DISEASE:
Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance) [MIM:270450]. IGF1 resistance is a gowth deficiency disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Contains 3 fibronectin type-III domains.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 3480 Human

Entrez Gene: 16001 Mouse

Entrez Gene: 25718 Rat

Omim: 147370 Human

SwissProt: P08069 Human

SwissProt: Q60751 Mouse

SwissProt: P24062 Rat

Unigene: 643120 Human

Unigene: 714012 Human

Unigene: 275742 Mouse

Unigene: 10957 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
亚洲aaaa级特黄毛片 | 国产丰满大乳无码免费播放 | 人善之交Z0OZO0D0G人善 | 无码高潮喷水在线播放观看 | 国产午夜福利亚洲第一 | 亚洲欧洲日本无在线码天堂 | 无套内射学生妹韩国电影 | 日本中文字幕乱码免费 | 中文字幕一区二区三区在线观看 | 久久国产V一级毛多内射 | 日本一级婬片A片免费播放曰i | 在线观看日本污污ww网站 | 美女祼体无遮挡又污又黄又爽视频在线看 | 日本乱妇乱子视频 | 免费一区二区三区久久 | 精品国产在天天线在线 | 日日噜噜夜夜狠狠久久丁香五月 | 久久天天躁狠狠躁夜夜躁2012 | 欧美精品人人做天天操夜夜操 | 亚洲综合精品伊人久久 | 免费麻花传媒剧国产MV | 全黄H全肉短篇禁乱NP慕浅浅 | 五十丰满熟妇性旺盛 | 风韵丰满熟妇啪啪区老熟熟女 | 一本久道综合在线无码人妻 | 亚洲一区精品在线 | 精品国产午夜福利精品推荐 | 全黄H全肉短篇禁乱NP慕浅浅 | 99精品无码一区二区毛片免费 | 欧美日产国产精品日产 | 黄色网站在线观看视频 | 久久另类精品欧美日韩高清精品不卡 | 国禁国产you女视频网站 | 国产一级无码免费不卡| 国产一区二区三区在线看片 | VR虚拟专区亚洲精品二区 | 久久人人爽人人澡人人高潮av | 射精区-区区三区 | 亚洲乱码国产乱码精品精乡村 | 18以下不能看的美女视频 | 一级毛片免费视频网站 |