亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
中文字幕日本最新乱码视频,亚洲人成人无码.WWW石榴
Rabbit Anti-Filaggrin/Gold Conjugated antibody (bs-6327R-Gold)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-6327R-Gold
英文名稱 Rabbit Anti-Filaggrin/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的絲聚蛋白/中間絲相關(guān)蛋白抗體
別    名 FLG; Epidermal filaggrin; Filaggrin precursor; Fillagrin; Profilaggrin; FILA_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul(10nm  15nm  35nm
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  細(xì)胞類型標(biāo)志物  細(xì)胞骨架  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 447kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Filaggrin
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009].

Function:
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.

Tissue Specificity:
Keratohyalin granules.

Post-translational modifications:
Filaggrin is initially synthesized as a large, insoluble, highly phosphorylated precursor containing many tandem copies of 324 AA, which are not separated by large linker sequences. During terminal differentiation it is dephosphorylated and proteolytically cleaved. The N-terminal of the mature protein is heterogeneous, and is blocked by the formation of pyroglutamate.
Undergoes deimination of some arginine residues (citrullination).

DISEASE:
Defects in FLG are the cause of ichthyosis vulgaris (VI) [MIM:146700]; also known as ichthyosis simplex. Ichthyosis vulgaris is the most common form of ichthyosis inherited as an autosomal dominant trait. It is characterized by palmar hyperlinearity, keratosis pilaris and a fine scale that is most prominent over the lower abdomen, arms, and legs. Ichthyosis vulgaris is characterized histologically by absent or reduced keratohyalin granules in the epidermis and mild hyperkeratosis. The disease can be associated with frequent asthma, eczema or hay fever.
Defects in FLG are a cause of susceptibility to dermatitis atopic type 2 (ATOD2) [MIM:605803]. Atopic dermatitis is a complex, inflammatory disease with multiple alleles at several loci thought to be involved in the pathogenesis. It commonly begins in infancy or early childhood and is characterized by a chronic relapsing form of skin inflammation, a disturbance of epidermal barrier function that culminates in dry skin, and IgE-mediated sensitization to food and environmental allergens. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee.

Similarity:
Belongs to the S100-fused protein family.
Contains 2 EF-hand domains.
Contains 23 filaggrin repeats.

Database links:

Entrez Gene: 2312 Human

Entrez Gene: 14246 Mouse

Omim: 135940 Human

SwissProt: P20930 Human

SwissProt: P11088 Mouse

Unigene: 654510 Human

Unigene: 162684 Mouse

Unigene: 439710 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
中文字幕高清免费日韩视频在线 | 欧美精品华人在线 | 成熟少妇大片免费看 | 麻豆国产精品无码AV在线 | 国产三级在线观看视频 | 久久精品国产亚洲AV四区 | 精品一区二区久久久久久久网精 | 国产精品免费视频一区二区三区 | 国产久爱青草视频在线观看 | 丰满老女人一级毛片视频 | 国产精品看片在线观看 | 亚洲精品视频在线免费观看 | 一级二级无码电影在线观看 | 亚洲一区二区三区高清网 | 日韩久久久久久无码精品 | 又大又紧又粗c死你视频 | 国产成人91亚洲精品无码观看 | 精品欧美一区二区三区成人片在线 | 99久久精品国产第一页 | 为您提供久久久久国产精品 | 午夜精品一区二区三区在线观看 | 久久免费观看视频 | 欧美大屁股XXXX高跟欧美黑人 | 欧美精品视频一区二区三区不卡 | 青春草视频在线观看 | 免费精品一区二区三区在线观看 | 成年女人免费播放专区 | 黄色网页在线免费观看 | 久久久精品国产亚洲AV无码 | 少妇无码太爽了视频在线播放 | 99久女女精品视频在线观看 | 伦人伦 XXX国语对白 | yellow片免费观看在线 | 欧美日韩一区精品视频一区二区 | 999精品视频这里只有精品 | 成 人3d动漫在线观看 | 国产精华液一级毛片久久久久久久女人18 | 丰满爆乳肉感一区二区三区 | 一二三四五在线播放免费观看中文版 | 国产精品免费视频一区二区三区 | a色毛片免费视频 |