亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
中文字幕日本最新乱码视频,亚洲人成人无码.WWW石榴
Rabbit Anti-Filaggrin/Gold Conjugated antibody (bs-6327R-Gold)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-6327R-Gold
英文名稱 Rabbit Anti-Filaggrin/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的絲聚蛋白/中間絲相關(guān)蛋白抗體
別    名 FLG; Epidermal filaggrin; Filaggrin precursor; Fillagrin; Profilaggrin; FILA_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul(10nm  15nm  35nm
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  細(xì)胞類型標(biāo)志物  細(xì)胞骨架  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 447kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Filaggrin
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009].

Function:
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.

Tissue Specificity:
Keratohyalin granules.

Post-translational modifications:
Filaggrin is initially synthesized as a large, insoluble, highly phosphorylated precursor containing many tandem copies of 324 AA, which are not separated by large linker sequences. During terminal differentiation it is dephosphorylated and proteolytically cleaved. The N-terminal of the mature protein is heterogeneous, and is blocked by the formation of pyroglutamate.
Undergoes deimination of some arginine residues (citrullination).

DISEASE:
Defects in FLG are the cause of ichthyosis vulgaris (VI) [MIM:146700]; also known as ichthyosis simplex. Ichthyosis vulgaris is the most common form of ichthyosis inherited as an autosomal dominant trait. It is characterized by palmar hyperlinearity, keratosis pilaris and a fine scale that is most prominent over the lower abdomen, arms, and legs. Ichthyosis vulgaris is characterized histologically by absent or reduced keratohyalin granules in the epidermis and mild hyperkeratosis. The disease can be associated with frequent asthma, eczema or hay fever.
Defects in FLG are a cause of susceptibility to dermatitis atopic type 2 (ATOD2) [MIM:605803]. Atopic dermatitis is a complex, inflammatory disease with multiple alleles at several loci thought to be involved in the pathogenesis. It commonly begins in infancy or early childhood and is characterized by a chronic relapsing form of skin inflammation, a disturbance of epidermal barrier function that culminates in dry skin, and IgE-mediated sensitization to food and environmental allergens. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee.

Similarity:
Belongs to the S100-fused protein family.
Contains 2 EF-hand domains.
Contains 23 filaggrin repeats.

Database links:

Entrez Gene: 2312 Human

Entrez Gene: 14246 Mouse

Omim: 135940 Human

SwissProt: P20930 Human

SwissProt: P11088 Mouse

Unigene: 654510 Human

Unigene: 162684 Mouse

Unigene: 439710 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
美妇乱人伦视频中文字幕 | 国产精品 久久久精品软件下载 | 亚洲日本一区二区一本一道 | 日韩国产自产拍av在线 | 亚洲欧美一区二区三区导航 | 品产品久精国精产拍20 | 一级做a爰片久久免费 | 亚洲A∨无码精品午夜电影 高清欧美在线三级视频 | 少妇人妻AV毛片在线看 | 国产精品久久国产三级国电话系列 | 2019午夜福利不卡片在线 | 最大胆裸体人体牲交666 | 国产在线视频福利 | 久久精品国产亚洲A片高清不卡 | 天天影视色香欲综合网老头 | 欧美mv日韩mv国产mv | 日韩中文字幕在线看视频免费 | 成人国产一区二区精品小说 | 无套内射极品少妇CHINESE | 日韩高清在线观看永久 | 又硬又粗又大一区二区三区视频 | 99久久免费精品高清特色大片 | 亚洲 欧美 自拍 美腿 卡通 | jk黑色丝袜美腿老师啪啪 | 日本羞羞裸色私人影院 | 中文区中文字幕免费看 | 色成人网站WWW永久在线观看 | 一本久道久久综合狠狠躁AV | 亚洲日本一线产区和二线产 | 国产精品久久久久精品一级APP | 50岁寡妇下面水多好紧 | 后入白嫩网红内射99XYZ | 欧美日韩无套内射另类 | 为您提供久久久久精品免费看 | 97人人爽人人爽爽人人一区二区 | 亚洲欧美色图小说 | 在线点播亚洲日韩国产欧美 | 欧美一性一交一免费看 | 亚洲精品成a人在线观看 | 国色天香视频免费高清社区 | 重口SM一区二区三区视频 |