亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
被两个两个黑人吃奶4P,亚州AV一级特黄大片
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-Filaggrin/PE-Cy3 Conjugated antibody (bs-6327R-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-6327R-PE-Cy3
英文名稱 Rabbit Anti-Filaggrin/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的絲聚蛋白/中間絲相關(guān)蛋白抗體
別    名 FLG; Epidermal filaggrin; Filaggrin precursor; Fillagrin; Profilaggrin; FILA_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  信號轉(zhuǎn)導  細胞周期蛋白  細胞類型標志物  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 447kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Filaggrin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009].

Function:
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.

Tissue Specificity:
Keratohyalin granules.

Post-translational modifications:
Filaggrin is initially synthesized as a large, insoluble, highly phosphorylated precursor containing many tandem copies of 324 AA, which are not separated by large linker sequences. During terminal differentiation it is dephosphorylated and proteolytically cleaved. The N-terminal of the mature protein is heterogeneous, and is blocked by the formation of pyroglutamate.
Undergoes deimination of some arginine residues (citrullination).

DISEASE:
Defects in FLG are the cause of ichthyosis vulgaris (VI) [MIM:146700]; also known as ichthyosis simplex. Ichthyosis vulgaris is the most common form of ichthyosis inherited as an autosomal dominant trait. It is characterized by palmar hyperlinearity, keratosis pilaris and a fine scale that is most prominent over the lower abdomen, arms, and legs. Ichthyosis vulgaris is characterized histologically by absent or reduced keratohyalin granules in the epidermis and mild hyperkeratosis. The disease can be associated with frequent asthma, eczema or hay fever.
Defects in FLG are a cause of susceptibility to dermatitis atopic type 2 (ATOD2) [MIM:605803]. Atopic dermatitis is a complex, inflammatory disease with multiple alleles at several loci thought to be involved in the pathogenesis. It commonly begins in infancy or early childhood and is characterized by a chronic relapsing form of skin inflammation, a disturbance of epidermal barrier function that culminates in dry skin, and IgE-mediated sensitization to food and environmental allergens. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee.

Similarity:
Belongs to the S100-fused protein family.
Contains 2 EF-hand domains.
Contains 23 filaggrin repeats.

Database links:

Entrez Gene: 2312 Human

Entrez Gene: 14246 Mouse

Omim: 135940 Human

SwissProt: P20930 Human

SwissProt: P11088 Mouse

Unigene: 654510 Human

Unigene: 162684 Mouse

Unigene: 439710 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
一级做a爱过程免费视频超级 | 免费少妇A级毛片野外大战 亚洲精品高清一二区久久 精品欧美一区二区三区成人片在线 | 成年女人免费播放专区 | 欧美日韩无线码免费播放器 | 99精品亚洲国产精品久久不卡 | 免费又黄又爽1000禁片 | 国产成人AV激情在线播放 | 99RE久久精品国产 | 丰满女教师中文字幕5 | 男男被一根又一根H强迫NP | 国产精品人人爽人人做Av片 | 99久久免费国产精品特黄 | 开心片色99xxxx | 真人短片20分钟以上 | 又粗又大的机巴好爽视频视频 | 国产精品久久久久精品一级APP | 国产精品美女乱子伦高 | 很狠干线观看2021 | 扒开腿挺进湿润的花苞HD视频 | 少妇被黑人到高潮喷出白浆 | 欧美bbbbbxxxxx | 一本大道加勒比久久 | 特黄三级又爽又粗又大洗澡 | 中文字幕在线免费观看 | 亚洲国产18成人中文字幕久久久久无码av | 超碰国产精品人人做人人爱 | 巨胸爆乳美女露双奶头挤奶 | 欧美日韩精品国产一区在线 | 欧美两根一起进3p在线观看 | 午夜福利免费一区二区小说 | 免费无毒a网站在线观看 | 在线看片免费人成视频电影sM | 一区二区三区视频在线观看 | 亚洲国产精品久久久久秋霞小 | 少妇高清精品毛片在线视频 | 日韩电影一二三区 | 成人无码片黄网站A毛片免费 | 久久99久久99精品免视看国产四区 | 欧美激情成a人在线观看 | 奇米成人影院777欧美极品 | 久久这里只有精品视频6 |