亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产AV日韩一区二区三区精品,欧美人与性囗牲恔配
Rabbit Anti-IRS1/RBITC Conjugated antibody (bs-0172R-RBITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-0172R-RBITC
英文名稱 Rabbit Anti-IRS1/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標(biāo)記的胰島素受體底物-1抗體
別    名 HIRS 1; HIRS1; Insulin Receptor Substrate 1; IRS-1; IRS 1; IRS1; OTTHUMP00000164234; IRS1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  糖尿病  內(nèi)分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig,  (predicted: Chicken, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 137kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from rat IRS-1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.

Function:
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

Subunit:
Interacts with UBTF and PIK3CA. Interacts (via phosphorylated YXXM motifs) with PIK3R1. Interacts with ROCK1 and FER. Interacts (via PH domain) with PHIP. Interacts with GRB2. Interacts with SOCS7. Interacts (via IRS-type PTB domain) with IGF1R and INSR (via the tyrosine-phosphorylated NPXY motif). Interacts with ALK.

Subcellular Location:
IRS1 is predominantly found in the cytoplasm. Nuclear localization may occur in some cell types and under specific stimuli.

Post-translational modifications:
Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
Phosphorylation of Tyr-896 is required for GRB2-binding.

DISEASE:
Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM)

Similarity:
Contains 1 IRS-type PTB domain.
Contains 1 PH domain.

Database links:

Entrez Gene: 3667 Human

Entrez Gene: 16367 Mouse

Entrez Gene: 25467 Rat

Omim: 147545 Human

SwissProt: P35568 Human

SwissProt: P35569 Mouse

SwissProt: P35570 Rat

Unigene: 471508 Human

Unigene: 4952 Mouse

Unigene: 10476 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

信號傳導(dǎo)(Signaling Intermediates)
胰島素受體底物-1是細(xì)胞中分子量為165-185kDa的磷蛋白,胰島素受體的內(nèi)源性底物。經(jīng)胰島素刺激后其酪氨酸殘基被磷酸化。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
精品久久久久久久久久中文字幕 | 免费精品国自产拍在线播放 | 在线视频一区二区三区四区 | 久久久SS麻豆欧美国产日韩 | 懂色av无码aV天天aV天天爽 | 在线观看欧美人与动物性交 | AV天堂午夜精品一区二区三区 | 奇米成人影院777欧美极品 | 亚洲AV日韩Av永久无码破 | 欧美日韩一区二区三区人妻 | 欧美日本在线不卡二区 | 国产AV无码一二三区天堂 | 公么大龟弄得我好舒服秀婷视频 | 无码午夜福利免费区久久 | 学生妹亚洲一区二区 | 国产超碰人人爱被IOS解锁 | 亚洲最大成人综合网720P | 永久免费观看的黄网站 | 国产变态拳头交视频免费播放 | 亚洲欧美日韩在线精品一区 | 欧美一级二级三级 | 啊…嗯啊好深男男腐文多人 | 人妻无码专区一专区二专区三 | 亚洲AV无码专区一级婬片毛片 | 日本乱人伦aⅴ精品潮喷 | 蜜桃视频一区二区 | 无码精品人妻一区二区三区免费 | 国产午夜无码精品免费看浪潮 | 久久AV无码专区亚洲桃花岛 | 国产精品久久久久久精品爆乳 | 大又大又粗又硬又爽少妇毛片 | 人妻体内射精一区二区三四 | 国产香蕉97碰碰久久人人蜜桃 | 97精品伊人久久大香线蕉 | 欧美日韩国产无线码一区 | 亚洲精品视频在线免费观看 | 小少妇BBBBBBBBBBBB | 老湿地影视体验区 | 精品国产90后在线观看 | 日本动态120秒免费 小宝极品内射国产在线 | 色妞色视频一区二区三区四区 |