亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
4399视频免费观看大全,婷婷无套内射影院,又黑又粗大棒插白妇口视频
Rabbit Anti-IRS1/AP Conjugated antibody (bs-0172R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-0172R-AP
英文名稱 Rabbit Anti-IRS1/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的胰島素受體底物-1抗體
別    名 HIRS 1; HIRS1; Insulin Receptor Substrate 1; IRS-1; IRS 1; IRS1; OTTHUMP00000164234; IRS1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  糖尿病  內(nèi)分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig,  (predicted: Chicken, )
產(chǎn)品應(yīng)用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 137kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from rat IRS-1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.

Function:
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

Subunit:
Interacts with UBTF and PIK3CA. Interacts (via phosphorylated YXXM motifs) with PIK3R1. Interacts with ROCK1 and FER. Interacts (via PH domain) with PHIP. Interacts with GRB2. Interacts with SOCS7. Interacts (via IRS-type PTB domain) with IGF1R and INSR (via the tyrosine-phosphorylated NPXY motif). Interacts with ALK.

Subcellular Location:
IRS1 is predominantly found in the cytoplasm. Nuclear localization may occur in some cell types and under specific stimuli.

Post-translational modifications:
Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
Phosphorylation of Tyr-896 is required for GRB2-binding.

DISEASE:
Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM)

Similarity:
Contains 1 IRS-type PTB domain.
Contains 1 PH domain.

Database links:

Entrez Gene: 3667 Human

Entrez Gene: 16367 Mouse

Entrez Gene: 25467 Rat

Omim: 147545 Human

SwissProt: P35568 Human

SwissProt: P35569 Mouse

SwissProt: P35570 Rat

Unigene: 471508 Human

Unigene: 4952 Mouse

Unigene: 10476 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

信號傳導(dǎo)(Signaling Intermediates)
胰島素受體底物-1是細(xì)胞中分子量為165-185kDa的磷蛋白,胰島素受體的內(nèi)源性底物。經(jīng)胰島素刺激后其酪氨酸殘基被磷酸化。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
欧美熟妇呻吟猛交XX性 | 99国精品午夜福利视频不卡 | 精品乱码一区二区三区四区 | 国产精品国产馆在线真实露脸 | 加勒比高清无码二区在线三级免费电影dvd | 精品国产人成亚洲区 | 91人妻无码精品一区二区毛片 | 国产欧美日韩综合一区在线播放 | 在线天堂新版最新版在线8 а√在线中文网新版地址在线 | 国模无码一区二区三区 | 99精品无人区乱码在线观看 | 国产真实乱子伦精品视频 | 国产伦精品一区二区三区免费 | 麻豆传播媒体免费版官网 | 中文字幕色综合久久 | 波多野结衣被躁57分钟 | 亚洲自偷自拍熟女另类 | 国产性自爱拍偷在在线播放 | 中文无码AV人妻一级字幕VR | 日韩AV无码一区二区三区不卡毛片 | 97精品国产高清自在线看超 | 性一交一无一伦一精一品视频 | 麻婆豆传媒一区二区三 | 麻豆精品一区二正一三区 | 男JI大巴进入女人的视频 | 国产亚洲AV片在线观看16女人 | 亚洲精品综合第一国产综合 | 小sao货水好多真紧 亚洲综合色婷婷七月丁香 国产精品内射久久久久欢欢 | 国产精品视频一区二区三区不卡 | 日本五月天婷久久网站 | 久久99免费视频 | 国产乱妇乱子视频在线播放国产 | 60老熟女多次高潮露脸视频 | 中国一级毛片在线观看 | 免费国产黄线在线观看 | 久久久精品久久久久久久久久久 | 国产午夜亚洲精品区 | 狠狠躁夜夜躁人人爽天天69 | 草莓黄瓜蜜桃视频app下载 | 国产欧美一区二区三区久久 | 成人免费毛片AAAAAA片 |