亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
成年18禁美女网站免费进入,麻豆一区产品精品蜜桃的广告语
Rabbit Anti-MMP9/PE-Cy5.5 Conjugated antibody (bs-4593R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-4593R-PE-Cy5.5
英文名稱 Rabbit Anti-MMP9/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的基質(zhì)金屬蛋白酶9抗體
別    名 Matrix metalloproteinase-9 precursor; MMP-9; MMP9; MMP 9; 92 kDa type IV; Collagenase; 92 kDa gelatinase; Gelatinase B; GELB; MMP9_HUMAN; 82 kDa matrix metalloproteinase-9; 92 kDa type IV collagenase; CLG 4B; CLG-4B; CLG4B; Collagenase Type 4 beta; Collagenase Type-4 beta; Collagenase type IV 92 KD; Collagenase type IV 92 KD; EC 3.4.24.35; Gelatinase 92 KD; Gelatinase 92 KD; Gelatinase beta; Gelatinase-beta; GelatinaseB; GELB; Macrophage gelatinase; MANDP2; Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); Matrix Metalloproteinase 9; Type V collagenase.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  合成與降解  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Dog,  (predicted: Mouse, Rat, Chicken, Pig, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 78kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MMP9
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
All cells within tissues are surrounded by an extracellular matrix (ECM) giving the tissues shape and structure. The ECM is constantly being remodeled and constant communication is maintained between cells through this matrix. Secreted proteins, termed matrix metalloproteinases (MMPs), are involved in the modulation of cell matrix interactions. MMPs are Zn(2+) binding endopeptidases that degrade various components of the ECM. MMPs are enzymes implicated in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. These enzymes are very potent when active, and are associated with extracellular space inhibitors called TIMPs (tissue inhibitors of matrix metalloproteinases). TIMPs have been shown to block tumor cell invasion suggesting that they act as metastasis suppressor genes.

Function:
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.

Subunit:
Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1.

Subcellular Location:
Secreted, extracellular space, extracellular

Tissue Specificity:
Produced by normal alveolar macrophages and granulocytes.

Post-translational modifications:
Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.
N- and O-glycosylated.

DISEASE:
Defects in MMP9 may be a cause of susceptibility to intervertebral disc disease (IDD) [MIM:603932]; also known as lumbar disk herniation (LDH). IDD is one of the most common musculo-skeletal disorders and the predominant cause of low-back pain and unilateral leg pain.
Defects in MMP9 are the cause of metaphyseal anadysplasia type 2 (MANDP2) [MIM:613073]. Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia.

Similarity:
Belongs to the peptidase M10A family.

Database links:

Entrez Gene: 403885 Dog

Entrez Gene: 4318 Human

Entrez Gene: 17395 Mouse

Entrez Gene: 81687 Rat

Omim: 120361 Human

SwissProt: O18733 Dog

SwissProt: P14780 Human

SwissProt: P41245 Mouse

SwissProt: P50282 Rat

Unigene: 297413 Human

Unigene: 4406 Mouse

Unigene: 10209 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

MMP9亦稱IV型膠原酶或明膠酶B,其主要功能為降解IV型膠原。因而它在腫瘤細(xì)胞突破基底膜屏障和浸潤轉(zhuǎn)移中起重要作用。目前主要用于各種惡性腫瘤(如乳腺癌、胃腸道癌、卵巢癌、膀胱癌等)中的基底膜檢測與轉(zhuǎn)移浸潤的研究。細(xì)胞外基質(zhì)在維持正常組織結(jié)構(gòu)與功能以及細(xì)胞生長和分化過程中起重要作用。細(xì)胞外基質(zhì)動態(tài)平衡的失調(diào)與腫瘤細(xì)胞侵襲、轉(zhuǎn)移和復(fù)發(fā)密切相關(guān),基質(zhì)金屬蛋白酶(MMP9)是細(xì)胞外基質(zhì)的降解酶,可降解Ⅳ、Ⅴ、Ⅸ、Ⅺ型膠原,在腫瘤的浸潤、轉(zhuǎn)移過程中起重要作用,近年為腫瘤研究的熱點(diǎn)。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产精品美女自在线观看免费 | 成人无码WWW免费视频网站 | 欧美一区二区精品久久久 | 久久九九日本韩国精品 | 久久久这里只有精品加勒比 | 国产精品看高国产精品不卡 | 久久人人爽人人人爽成人AV片 | 99精品亚洲国产精品久久不卡 | 最近免费中文字幕大全高清大全1 | 97se亚洲综合自在线尤物 | 欧美精品九九99久久在观看 | 久久人人爽人人人爽成人AV片 | 久久成人永久免费播放 | 精品无码久久久久久久久 | 么公又大又硬又粗又长 | 国产伦精品一区二区三区妓女 | 国模无码一区二区三区 | 国产美女视频一区二区二三区 | 日本花心黑人hd捆绑 | 国产午夜影视大全免费观看 | 欧美又大又粗又硬又色A片 国产精品久久久天天影视香蕉 | 内射无套在线观看高清完整免费 | 最近免费中文字幕大全高清大全1 | 囯精产品一品二品国精91 | 免费国产va在线观看中文字 | 久久夜色精品国产噜噜亚洲av | 欧美日韩激情在线一区二区三区 | 业佘老头视频man4 | 国产二区三区中文字幕 | 黄区1区2区3区4区5区 | 色婷婷久综合久久一本国产AV | 一级做a爰片久久毛片潮喷妓女免费 | 狼人久蕉在线播放 | 最近中文字幕在线看免费完整版 | 曰韩欧美群交P片内射 | 国产呦精品一区二区三区下载 | 国产精品你当然比游戏重要 | 特黄三级又爽又粗又大 | 亚洲欧美一区二区三区图片 | 动漫人物自慰喷水网站 | 最新黄色网址在线观看 |