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Rabbit Anti-CEND1/BF555 Conjugated antibody (bs-7858R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-7858R-BF555
英文名稱 Rabbit Anti-CEND1/BF555 Conjugated antibody
中文名稱 BF555標記的細胞周期通道和神經(jīng)細胞分化蛋白1抗體
別    名 BM88; BM88 antigen; Cell cycle exit and neuronal differentiation 1; Cell cycle exit and neuronal differentiation protein 1; FLJ90066; MGC34326; CEND_HUMAN  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經(jīng)生物學  細胞周期蛋白  細胞分化  細胞類型標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Horse, )
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 15kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CEND1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
BM88 is a 149 amino acid protein that belongs to the CEND1 familly. Involved in neuroblastoma cell differentiation, BM88 is a single-pass type IV membrane protein that is neuron specific. It is suggested that BM88 forms a dimer of two identical polypeptides linked by disulfide bridges. BM88 has a central proline-rich region containing four PxxP motifs, which typically bind SRC homology-3 (SH3) domains, as well as a putative C-terminal transmembrane region, and several potential sites for N-glycosylation, myristoylation and phosphorylation. It is also suggested that a novel signaling mechanism exists by which BM88 interferes with calcium release from inositol 1,4,5-trisphosphate-sensitive stores and exerts anti-proliferative and anti-apoptotic functions. BM88 is an important molecular target for HDAC inhibition, and transcription of BM88 is induced by trichostatin-A.

Function:
CEND1 is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene.

Subunit:
Homodimer

Subcellular Location:
Membrane; Single-pass type IV membrane protein.

Tissue Specificity:
Neuron specific.

Similarity:
Belongs to the CEND1 family.

Database links:

Entrez Gene: 51286 Human

Entrez Gene: 57754 Mouse

Entrez Gene: 361675 Rat

Omim: 608213 Human

SwissProt: Q8N111 Human

SwissProt: Q9JKC6 Mouse

SwissProt: Q5FVI4 Rat

Unigene: 22140 Human

Unigene: 87027 Mouse

Unigene: 64460 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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