亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
毛片免费全部免费观看,开心片色99xxxx
Rabbit Anti-phospho-PP2A alpha+beta(Tyr307)/Gold Conjugated antibody (bs-6419R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-6419R-Gold
英文名稱 Rabbit Anti-phospho-PP2A alpha+beta(Tyr307)/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的磷酸化蛋白磷酸酶2A(PP2Aα)抗體
別    名 p-PP2A-Cα/β; PP2A alpha (phospho Y307); p-PP2A alpha(Y307); PP2A A; PP2A alpha; PP2A B; PP2A beta; PP2Ac; PP2C alpha; PP2C beta; PP2CA; PP2CB; PPP2CA; PPP2CB; Protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform; Protein phosphatase 2 (formerly 2A) catalytic subunit beta isoform; Protein phosphatase 2; Protein phosphatase 2 catalytic subunit alpha isoform; Protein phosphatase 2 catalytic subunit beta isoform; Protein Phosphatase 2A; Protein phosphatase type 2A catalytic subunit; Replication protein C; RP C; Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform; Serine/threonine protein phosphatase 2A catalytic subunit beta isoform; Serine/threonine protein phosphatase.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul(10nm  15nm  35nm
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞周期蛋白  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human PPP2CA around the phosphorylation site of Tyr307
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008].

Function:
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. Activates RAF1 by dephosphorylating it at 'Ser-259'.

Subunit:
PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with NXN; the interaction is direct (By similarity). Interacts with TP53, SGOL1 and SGOL2. Interacts with AXIN1; the interaction dephosphorylates AXIN1. Interacts with PIM3; this interaction promotes dephosphorylation, ubiquitination and proteasomal degradation of PIM3. Interacts with RAF1.

Subcellular Location:
Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2.

Post-translational modifications:
Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly, enhancing the affinity of the PP2A core enzyme for some, but not all, regulatory subunits. It varies during the cell cycle.
Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.

Similarity:
Belongs to the PPP phosphatase family. PP-1 subfamily.

Database links:

Entrez Gene: 416318 Chicken

Entrez Gene: 282320 Cow

Entrez Gene: 5515 Human

Entrez Gene: 19052 Mouse

Entrez Gene: 397656 Pig

Entrez Gene: 100009252 Rabbit

Entrez Gene: 24672 Rat

Omim: 176915 Human

SwissProt: P48463 Chicken

SwissProt: P67774 Cow

SwissProt: P67775 Human

SwissProt: P63330 Mouse

SwissProt: P67776 Pig

SwissProt: P67777 Rabbit

SwissProt: P63331 Rat

Unigene: 105818 Human

Unigene: 260288 Mouse

Unigene: 1271 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
97久久久人妻一区精品 | 无遮无挡试看120秒动态图 | 无码AV天堂亚洲内射夫妻 | 日韩成人大屁股内射喷水 | 每日更新在线观看av | 国产福利一区二区三区在线观看 | 亚洲精品成A人在线观看 | 日韩大片高清播放器大全 | 亚洲二区在线视频 | 久久综合亚洲鲁鲁五月天欧美 | 久色乳综合思思在线视频 | 欧洲精品免费视频在线观看 | 国产a级三级三级成人国产一级婬片 | 欧美日韩一区二区三区人妻 | 久久久久久久成人午夜精品福利 | 青青青免费高清在线观看一区二区 | 国产猛男猛女超爽免费视频 | 成年片色大黄全免费网站观看 | 1级a的观看视频 | 久久天天躁狠狠躁夜夜躁 | 永久免费观看国产裸体美女 | 欧美三级在线免费观看 | 老师你下面太紧进不去小黄文 | 91久久精品国产免费一区金莲 | 美女网站在线观看视频18 | 久久窝窝国产精品午夜看片 | 边做饭边被躁在线播放 | 亚洲v无码专区国产乱码一区二区 | 在线精品自偷自拍无码 | 日韩成人大屁股内射喷水 | 久久se精品一区精品二区 | 日韩欧美在线观看成人 | 欧美日韩中文字幕群交视频在线观看 | 国产麻豆成人传媒免费观看 | 中文字幕日韩人妻在线乱码 | 国产sm精品调教在线 | 又紧又大又爽精品一区二区 | 久久久久亚洲Av片无码 | 欧美人妻AⅤ中文字幕 | 丰满少妇被猛烈进AV毛片 | 噜噜色青草久久丁香伊人 |