亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
久久国产欧美日韩精品免费 ,一本色道久久a久久精品综合网站免费,强行糟蹋人妻HD中文字幕
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-PP2A alpha+beta(Tyr307)/BF488 Conjugated antibody (bs-6419R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-6419R-BF488
英文名稱 Rabbit Anti-phospho-PP2A alpha+beta(Tyr307)/BF488 Conjugated antibody
中文名稱 BF488標記的磷酸化蛋白磷酸酶2A(PP2Aα)抗體
別    名 p-PP2A-Cα/β; PP2A alpha (phospho Y307); p-PP2A alpha(Y307); PP2A A; PP2A alpha; PP2A B; PP2A beta; PP2Ac; PP2C alpha; PP2C beta; PP2CA; PP2CB; PPP2CA; PPP2CB; Protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform; Protein phosphatase 2 (formerly 2A) catalytic subunit beta isoform; Protein phosphatase 2; Protein phosphatase 2 catalytic subunit alpha isoform; Protein phosphatase 2 catalytic subunit beta isoform; Protein Phosphatase 2A; Protein phosphatase type 2A catalytic subunit; Replication protein C; RP C; Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform; Serine/threonine protein phosphatase 2A catalytic subunit beta isoform; Serine/threonine protein phosphatase.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  心血管  細胞生物  免疫學  神經生物學  信號轉導  干細胞  細胞周期蛋白  轉錄調節(jié)因子  激酶和磷酸酶  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human PPP2CA around the phosphorylation site of Tyr307
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008].

Function:
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. Activates RAF1 by dephosphorylating it at 'Ser-259'.

Subunit:
PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with NXN; the interaction is direct (By similarity). Interacts with TP53, SGOL1 and SGOL2. Interacts with AXIN1; the interaction dephosphorylates AXIN1. Interacts with PIM3; this interaction promotes dephosphorylation, ubiquitination and proteasomal degradation of PIM3. Interacts with RAF1.

Subcellular Location:
Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2.

Post-translational modifications:
Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly, enhancing the affinity of the PP2A core enzyme for some, but not all, regulatory subunits. It varies during the cell cycle.
Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.

Similarity:
Belongs to the PPP phosphatase family. PP-1 subfamily.

Database links:

Entrez Gene: 416318 Chicken

Entrez Gene: 282320 Cow

Entrez Gene: 5515 Human

Entrez Gene: 19052 Mouse

Entrez Gene: 397656 Pig

Entrez Gene: 100009252 Rabbit

Entrez Gene: 24672 Rat

Omim: 176915 Human

SwissProt: P48463 Chicken

SwissProt: P67774 Cow

SwissProt: P67775 Human

SwissProt: P63330 Mouse

SwissProt: P67776 Pig

SwissProt: P67777 Rabbit

SwissProt: P63331 Rat

Unigene: 105818 Human

Unigene: 260288 Mouse

Unigene: 1271 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
日韩美乳诱惑专区 | 成人无码精品1区2区3区免费看 | 直接看的av网址免费的 | 三级毛片在线播放 | 欧美一区二区在线观看 | 囯产精品一品二区三区 | 精品国产鲁一鲁一区二区66AV | 欧美日韩一区精品视频一区二区 | 欧美三级片a片在线观看 | 中文字幕亚洲第一 | 性妇WBBBB搡BBBB嗓1 | 性欧美18处19处破在线观看 | 女人高潮爽到全身痉挛抽搐 | 亚洲一级毛片无码专区 | 久久久97精品国产一区蜜桃 | 内地级A艳片高清免费播放 国产精品无码不卡系列在线 | 亚洲中文字幕每日更新 | 日韩综合在线观看 | 久久狠狠爱亚洲综合影院 | 黄乱色伦短篇小说 | 亚洲区中文字幕在线不卡电影 | 很黄很黄地在床视频女 | 色国产精品一区在线观看 | 国产乱妇乱子视频在线播放国产 | 亚洲精品综合第一国产综合 | 久久亚洲美日韩精品无码一区二区 | 日韩一区二区免费视频 | 久久国产精品久久国产精品 | 91精品国产高清一区二区三密臀 | 国产人成无码视频在线观看 | 精品国产乱码久久久久久小说 | 国产欧美日韩网站 | 懂色av无码aV天天aV天天爽 | 久久亚洲精品国产亚洲老地址 | 少妇的奶头又大又红又涨 | 精品国产AV无码喷奶水麻豆 | 国语对白露脸XXXXXX | 亚州一级一片无码内射 | 精品无人乱码高清在线观看 | 亚洲二区在线视频 | 国产午夜片无码区在线观看爱情网 |