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Rabbit Anti-LHR/Gold Conjugated antibody (bs-6431R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-6431R-Gold
英文名稱 Rabbit Anti-LHR/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的促黃體生成素受體抗體
別    名 Gonadotropin receptor; CGR; hCG receptor; FLJ41504; Gpcr19-rs1; GTHR-II; HHG; LCGR; LGR2; LH-R; LH/CG R; LH/CG-R; LH RECEPTOR; LH/CGR; LHCGR; LHR; LHRHR; LSH R; LSH-R; LSHR_HUMAN; Luteinizing hormone receptor; Luteinizing hormone/choriogonadotropin receptor; luteinizing hormone/choriogonadotropin receptor; Lutropin choriogonadotropic hormone receptor; Lutropin choriogonadotropic receptor; Lutropin-choriogonadotropic hormone receptor; ULG5.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  生長因子和激素  內(nèi)分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 74kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LHR/CGR
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq]

Function:
Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Gonadal and thyroid cells.

DISEASE:
Familial male precocious puberty (FMPP) [MIM:176410]: In FMPP the receptor is constitutively activated. Note=The disease is caused by mutations affecting the gene represented in this entry.
Luteinizing hormone resistance (LHR) [MIM:238320]: An autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Contains 6 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain.

Database links:

Entrez Gene: 3973 Human

Entrez Gene: 25477 Rat

Omim: 152790 Human

SwissProt: P22888 Human

SwissProt: P16235 Rat

Unigene: 468490 Human

Unigene: 11216 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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