亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
成人夜剧电影在线播放,国产美女视频一区二区二三区
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-NIPA/Cy5 Conjugated antibody (bs-8363R-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-8363R-Cy5
英文名稱 Rabbit Anti-NIPA/Cy5 Conjugated antibody
中文名稱 Cy5標記的間變性淋巴瘤激酶核相互作用伴侶蛋白抗體
別    名 hNIPA; Nuclear interacting partner of ALK; Nuclear interacting partner of anaplastic lymphoma kinase; ZC3HC1; Zinc finger C3HC type containing 1; NIPA_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細胞生物  免疫學  染色質(zhì)和核信號  信號轉(zhuǎn)導  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NIPA
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The regulated oscillation of protein expression is an essential mechanism of cell cycle control. The SCF class of E3 ubiquitin ligases is involved in this process by targeting cell cycle regulatory proteins for degradation by the proteasome, with the F-box subunit of the SCF specifically recruiting a given substrate to the SCF core. NIPA (nuclear interaction partner of ALK) is a human F-box-containing protein that defines an SCF-type E3 ligase (SCFNIPA) controlling mitotic entry. Assembly of this SCF complex is regulated by cell-cycle-dependent phosphorylation of NIPA, which restricts substrate ubiquitination activity to interphase. Nuclear cyclin B1 is a substrate of SCFNIPA. Inactivation of NIPA by RNAi results in nuclear accumulation of cyclin B1 in interphase, activation of cyclin B1-Cdk1 kinase activity, and premature mitotic entry. Thus, SCFNIPA-based ubiquitination may regulate S-phase completion and mitotic entry in the mammalian cell cycle.

Function:
Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.

Subunit:
Interacts with the NPM-ALK fusion protein in a tyrosine phosphorylation-dependent manner. Interacts with SKP1. Component of a SCF(NIPA) E3 complex with SKP1, RBX1 and CUL1 when not phosphorylated on Ser-354. Interacts with CCNB1.

Subcellular Location:
Nuclear

Tissue Specificity:
Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes.

Post-translational modifications:
Phosphorylated. Phosphorylated on Ser residues at G2/M phase, but not during S and G0 phases. May also be weakly phosphorylated on Tyr residues. Ser-354 phosphorylation, a major site during the course of cell-cycle-dedendent phosphorylation, results in its dissociation from the SCF(NIPA) complex, thereby preventing CCNB1 degradation leading to mitotic entry.

Similarity:
Contains 1 C3HC-type zinc finger.

Database links:

Entrez Gene: 51530 Human

Entrez Gene: 232679 Mouse

Entrez Gene: 296957 Rat

SwissProt: Q86WB0 Human

SwissProt: Q80YV2 Mouse

Unigene: 194157 Human

Unigene: 29780 Mouse

Unigene: 474686 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
a毛片在线看免费观看 | 在线免费观看黄色视频 | 黄应用色版app下载 亚洲国产精品特色大片观看完整版 | 又粗又猛又黄又爽无遮挡 | 久久久久国产精品喷潮免费观看臀 | 91免费精品国自产拍在线可以看 | 日本VS亚洲VS韩国一区三区四区 | 久久99精品久久久久久清纯直播 | 91热久久免费频精品动漫99 | 中文字幕乳桑田授乳奶水电影 | 国产激情无码久久久久久 | 免费AV岛国大片在线观看 | 搡老熟女老女人一区二区三区 | 欧美巨鞭大战丰满少妇 | 亚洲一区二区免费看 | 久久频这里精品99香蕉久网址 | 国产色XX群视频射精 | 性啪啪chinese东北女人 | 成人无码片黄网站A毛片免费 | 日韩丰满少妇无吗视频激情内射 | 国产AAAAA一级毛片无下载 | 精品久久久亚洲精品中文字幕 | 毛片线看免费观看 | 久久国产精品99精国产 | 动漫人物自慰喷水网站 | 高清少妇熟女一区二区 | 啊轻点内射在线视频 | 成人无码片黄网站A毛片免费 | 91影视永久福利免费观看 | 超嫩校花被灌醉在线观看 | 无码专区—VA亚洲V天堂麻豆 | 无码国产精品一区二区免费式芒果 | 国产欧美日本在线 | 国产性生大片免费观看性 | 精品国产乱码久久久久久浪潮 | 亚洲已满18点击进入在线观看 | 日本韩国亚洲综合日韩欧美国产 | 国产欧美日韩灭亚洲精品 | 一本一本久久a久久精品66 | 欧美一级做a爰片免费 | 欧日韩无套内射变态 |