亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
九九在线精品视频,日韩欧美一及在线播放
Rabbit Anti-NIPA/PE-Cy3 Conjugated antibody (bs-8363R-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-8363R-PE-Cy3
英文名稱 Rabbit Anti-NIPA/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標(biāo)記的間變性淋巴瘤激酶核相互作用伴侶蛋白抗體
別    名 hNIPA; Nuclear interacting partner of ALK; Nuclear interacting partner of anaplastic lymphoma kinase; ZC3HC1; Zinc finger C3HC type containing 1; NIPA_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號  信號轉(zhuǎn)導(dǎo)  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NIPA
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The regulated oscillation of protein expression is an essential mechanism of cell cycle control. The SCF class of E3 ubiquitin ligases is involved in this process by targeting cell cycle regulatory proteins for degradation by the proteasome, with the F-box subunit of the SCF specifically recruiting a given substrate to the SCF core. NIPA (nuclear interaction partner of ALK) is a human F-box-containing protein that defines an SCF-type E3 ligase (SCFNIPA) controlling mitotic entry. Assembly of this SCF complex is regulated by cell-cycle-dependent phosphorylation of NIPA, which restricts substrate ubiquitination activity to interphase. Nuclear cyclin B1 is a substrate of SCFNIPA. Inactivation of NIPA by RNAi results in nuclear accumulation of cyclin B1 in interphase, activation of cyclin B1-Cdk1 kinase activity, and premature mitotic entry. Thus, SCFNIPA-based ubiquitination may regulate S-phase completion and mitotic entry in the mammalian cell cycle.

Function:
Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.

Subunit:
Interacts with the NPM-ALK fusion protein in a tyrosine phosphorylation-dependent manner. Interacts with SKP1. Component of a SCF(NIPA) E3 complex with SKP1, RBX1 and CUL1 when not phosphorylated on Ser-354. Interacts with CCNB1.

Subcellular Location:
Nuclear

Tissue Specificity:
Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes.

Post-translational modifications:
Phosphorylated. Phosphorylated on Ser residues at G2/M phase, but not during S and G0 phases. May also be weakly phosphorylated on Tyr residues. Ser-354 phosphorylation, a major site during the course of cell-cycle-dedendent phosphorylation, results in its dissociation from the SCF(NIPA) complex, thereby preventing CCNB1 degradation leading to mitotic entry.

Similarity:
Contains 1 C3HC-type zinc finger.

Database links:

Entrez Gene: 51530 Human

Entrez Gene: 232679 Mouse

Entrez Gene: 296957 Rat

SwissProt: Q86WB0 Human

SwissProt: Q80YV2 Mouse

Unigene: 194157 Human

Unigene: 29780 Mouse

Unigene: 474686 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
日韩成人精品视频免费专区 | 影音先锋av男人资源 | 91免费视频网站 | 大学生一级毛片全黄真人无码 | 国产男人午夜视频在线观看 | 91TV国产人成在线播放免费 | 国产成人精品免高潮在线观看 | 人妻少妇偷人精品久久人妻 | 亚洲精品国产A久久久久久 91手机在线视频观看 | 2021国产麻豆剧传媒免费下载 | 国内久久久久久久久久 | 色综合久久88色综合天天 | 777久久精品一区二区三区无码 | 一级做a爰片久久毛片免费陪 | 久久久久精品国产亚洲HAV无码 | 久久精品中文骚妇内射AV | 亚洲精品美女久久久久99 | 免费伦费一区二区三区四区 | 人妻体体内射精一区二区三区电影 | 人妻少妇精品无码专区喷水 | 国产亚洲色婷婷久久99精品 | 熟妇人妻久久中文字幕麻豆网 | 国产欧美精品一区二区三区-老狼 | 欧美性猛交XXXX乱大交极品 | 久久久久久久Aⅴ无码免费网站 | 我们日本在线观看免费动漫下载 | 国产末成年AV一区二区三区 | 成年在线观看免费高清完整版视频 | 最近免费中文字幕大全高清MV | 成人午夜国产内射主播 | 精品无人区一区二区三区 | 免费A级毛片无码无遮挡内射 | 中文天堂在线WWW最新版官网 | 久久天天躁狠狠躁夜夜躁2012 | 国产精品美女免费视频观看 | 精品国产午夜肉伦伦影院 | 久久久久精品日韩久久久 | 一品二品三品免费看 | 欧美日韩国产免费一区二区三区 | 国产刺激高潮免费不卡 | 国产91三级精选国产 |