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Rabbit Anti-HAGHL/APC Conjugated antibody (bs-8414R-APC)
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訂購(gòu)QQ:  400-901-9800
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-8414R-APC
英文名稱(chēng) Rabbit Anti-HAGHL/APC Conjugated antibody
中文名稱(chēng) APC標(biāo)記的羥基酰谷胱甘肽水解酶樣蛋白抗體
別    名 HAGHL; HAGHL_HUMAN; Hydroxyacylglutathione hydrolase-like; Hydroxyacylglutathione hydrolase-like protein.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  Alzheimer's  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 32kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HAGHL
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The hydroxyacylglutathione hydrolase-like protein (HAGHL) is a 290 amino acid protein that belongs to the glyoxalase II family. HAGHL binds two zinc ions per subunit and acts as a hydrolase on ester bonds. The gene encoding HAGHL maps to human chromosome 16, which encodes over 900 genes in approximately 90 million base pairs, makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The rare disorder Rubinstein-Taybi syndrome is associated with chromosome 16, as is Crohn's disease, a gastrointestinal inflammatory condition that may involve the NOD2 gene. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier.

Function:
Hydroxyacylglutathione hydrolase (HAGH) is a thiolesterase which hydrolyses S-lactoyl-glutathione to reduced glutathione and D-lactate.

Subcellular Location:
Cytoplasmic and Mitochondrial

Similarity:
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Database links:

Entrez Gene: 84264 Human

SwissProt: Q6PII5 Human

Unigene: 124015 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

克羅恩病(節(jié)段性腸炎)Crohn’s disease(segmental enteritis”,曾稱(chēng):克隆病)的研究。
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