亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
亚洲欧美日韩国产精品一区二区 ,最近中文字幕高清字幕MV
Rabbit Anti-Lin28/Gold Conjugated antibody (bs-8443R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-8443R-Gold
英文名稱 Rabbit Anti-Lin28/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的RNA結(jié)合蛋白LIN28抗體
別    名 Lin 28; Lin28A; Lin 28 homolog (C. elegans); Lin 28 homolog A; Lin 28 homolog; Lin-28;y Lin-28 homolog (C. elegans); Lin-28 homolog A; Lin-28A; Lin28; Lin28a; LN28A_HUMAN; Protein lin-28 homolog A; RNA binding protein lin 28; RNA binding protein lin-28; Tex17; ZCCHC1; Zinc finger CCHC domain containing 1; Zinc finger CCHC domain containing protein 1; Zinc finger CCHC domain-containing protein 1; AL024421; CSDD1.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  發(fā)育生物學(xué)  神經(jīng)生物學(xué)  干細(xì)胞  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 29kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Lin28
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
LIN-28 is a highly conserved, RNA-binding, cytoplasmic protein. It consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs that were first identified in Caenorhabditis elegans. LIN-28 controls the timing of events during embryonic development and is readily expressed in embryos, embryonic stem cells and embryonal carcinoma cells. The presence of LIN-28 persists in some adult tissues including cardiac and skeletal muscle. In differentiating myoblasts, LIN-28 increases protein synthesis efficiency and binds to the growth and differentiation factor IGF-II.

Function:
Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.

Subunit:
Monomer. During skeletal muscle differentiation, associated with translation initiation complexes in the polysomal compartment. Directly interacts with EIF3S2. Interaction with NCL is RNA-dependent (By similarity). Interacts with ZCCHC11/TUT4.

Subcellular Location:
Cytoplasm. Nucleus > nucleolus. Nucleolar localization observed in 10-15% of the nuclei in differentiated myotubes (By similarity). Shuttles between the cytoplasm and the nucleus. Localizes to cytoplasmic processing bodies and stress granules.

Tissue Specificity:
Expressed in embryonic stem cells (ES cells), placenta and testis.

Similarity:
Belongs to the lin-28 family.
Contains 2 CCHC-type zinc fingers.
Contains 1 CSD (cold-shock) domain.

Database links:

Entrez Gene: 79727 Human

Entrez Gene: 83557 Mouse

Entrez Gene: 500562 Rat

Omim: 611043 Human

SwissProt: Q9H9Z2 Human

SwissProt: Q8K3Y3 Mouse

Unigene: 86154 Human

Unigene: 302567 Mouse

Unigene: 147538 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
中日韩免视频上线全都免费 | 亚洲高清成人AV电影网站 | 性夜影院爽黄A爽免费动漫 亚洲黄色一级大片 | 欧美最猛黑人xxxx黑人猛交 | 亚洲国产精品高清免费在线观看 | 豆奶视频在线观看免费高清版 | 在线A亚洲老鸭窝天堂AV高清 | 搡女人免费免费视频观看 | 在线观看国产精品第一区免费 | 一级av一片久久免费观看 | 91久久精品国产亚洲 | 伊人福利视频导航 | 午夜精品成人一区二区视频 | 一本一道久久a久久综合蜜桃 | 少妇高潮好爽在线播放 | 色妞AV永久一区二区国产AV开 | 荡公乱妇蒂芙尼中文字幕 | 亚洲中文字幕无码久久1 | 精品人妻无码中文字幕第一区 | 永久免费观看国产裸体美女 | 看亚洲A级一级毛片,亚洲AV片 | 老司机无码精品A | 60老熟女多次高潮露脸视频 | 91欧洲在线视精品在亚洲 | 公车痴汉媚药强抹在线观看 | 日日碰狠狠添天天爽无码av | 国产在线精品亚洲另类 | 在线天堂新版最新版在线8 а√在线中文网新版地址在线 | 日韩字幕在线观看一二三四区 | 九九热这里只有国产精品 | 久久久久久成人毛片免费看 | 一级毛片免费观看不卡的 | 久久er热在这里只有精品66 到这里 | 恩恩呜呜好大好爽快点 | 日韩人妻无码精品-专区 | 亚洲精品无码不卡在线播HE | 国产午夜亚洲精品区 | 国偷自产AV一区二区三区健身房 | 中文字幕在线视频一区 | 欧美综合自拍亚洲综合图 | 欧美黑人又粗又大XXXX视频 |