亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
日本一区二区三区在线网,久久se精品一区二区国产,精品久久久久久无码中文字幕动漫
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-GluR1 (Ser849)/BF555 Conjugated antibody (bs-8446R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-8446R-BF555
英文名稱 Rabbit Anti-phospho-GluR1 (Ser849)/BF555 Conjugated antibody
中文名稱 BF555標記的磷酸化谷氨酸受體1抗體
別    名 GluR1 (phospho Ser849); GluR1 (phospho S849); p- GluR1(Ser849); p- GluR1(S849); GLUR 1; GLUR A; AMPA 1; AMPA selective glutamate receptor 1; GLUH 1; GLUH1; GluR K1; GluR-1; GluR-A; GluR-K1; GLUR1; GLURA ; GluRK1; Glutamate receptor 1; Glutamate receptor ionotropic AMPA 1; Gria 1; Gria1 ; Gria1; HBGR1; MGC133252.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  免疫學  神經生物學  信號轉導  細胞凋亡  轉錄調節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Horse, Sheep, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 98kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human GluR1 around the phosphorylation site of Ser849 [QQ(p-S)IN]
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Subunit:
Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Interacts with SYNDIG1 and GRIA2. Interacts with LRFN. Interacts with HIP1 and RASGRF2. Found in a complex with GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5. Interacts with CNIH2 and CACNG2.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrit. Cell projection, dendritic spine. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression.

Tissue Specificity:
Widely expressed in brain.

Post-translational modifications:
Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.

Similarity:
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.

Database links:

Entrez Gene: 2890 Human

Entrez Gene: 14799 Mouse

Entrez Gene: 50592 Rat

Omim: 138248 Human

SwissProt: P42261 Human

SwissProt: P23818 Mouse

SwissProt: P19490 Rat

Unigene: 519693 Human

Unigene: 4920 Mouse

Unigene: 29971 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

NMDAR1又稱GluR1 (Glutamate Receptor 1)近年實驗研究發(fā)現(xiàn),許多NMDAR拮抗藥均具有鎮(zhèn)痛活性,表明NMDAR在痛覺傳遞中具有重要作用,這為新型鎮(zhèn)痛藥的研究開發(fā)提供了新的作用靶點。
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
国产黄a一级二级三级看三区 | 超级乱淫片午夜电影网99 | 97无码免费人妻超级碰碰夜夜 | 91精品国产麻豆国产自产在线 | 国产精品久久一区二区三蜜桃 | 无码中文字幕热热久久 | 视频一区二区三区蜜桃麻豆 | 精品无码国产AV一区二区性色 | 精品视频在线一区 | 国产高潮精品呻吟久久∧v无码 | 尤物久久99热国产综合 | 中文字幕看片在线a免费 | 性短视频在线观看免费不卡流畅 | 蜜桃羞羞小视频在线观看 | 插我舔内射18免费视频 | 国内精品伊人久久久久 | 国产精品亚洲av综合成久久久久久三级 | 毛片免费全部免费观看 | 日本一上一下爱爱免费 | 日韩一区二区在线观看视频 | 欧美香蕉大胸在线视频观看 | 97在线精品视频免费 | 国产一级Av片在线观看 | 最大胆裸体人体牲交666 | 91九色精品熟女内射 | www.色av.com| 国产精品久久久久久精品爆乳 | 老外和中国女人毛片免费视频 | 国产精品国产三级国产AV剧情 | 欧美群交XXXCOM | 亚洲欧美中文字幕5发布 | 狂躁美女BBBBBB视频 | 亚洲午夜福利在线视频 | 国产又大又硬又粗 | 国产精品一区二区资源 | 成人免费大片黄在线播放 | 国产成人精品日本亚洲11 | 免费一级欧美大片视频APP | 日韩欧美一区二区三区免费观看 | 久久久久久久国产 | 国产久爱青草视频在线观看 |