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Rabbit Anti-NIS/BF594 Conjugated antibody (bs-0448R-BF594)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0448R-BF594
英文名稱 Rabbit Anti-NIS/BF594 Conjugated antibody
中文名稱 BF594標(biāo)記的鈉碘轉(zhuǎn)運(yùn)體蛋白抗體
別    名 Na(+)/I(-) cotransporter; Na(+)/I(-) symporter; Na(+)/I(-) cotransporter; Na(+)/I(-) symporter; Na+/I- cotransporter; Na+/I-symporter; NIS; SC5A5_HUMAN; SLC5A5; sodium iodide symporter; Sodium-iodide symporter; Sodium/iodide cotransporter; Solute carrier family 5 (sodium iodide symporter) member 5; Solute carrier family 5; Solute carrier family 5 member 5.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 免疫學(xué)  通道蛋白  轉(zhuǎn)運(yùn)蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 68kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NIS C-terminus
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
catalyzes Na+/I- symporter activity plays a role in iodide transport and thyroid hormone generation.
Human Sodium Iodide Symporter (hNIS) is responsible for iodide concentrating ability within thyroid follicular cells. It is a membrane bound glycoprotein with 13 membrane spanning domains and 14 extramembranous domains. It may represent an autoantigen in thyroid.

Function:
Mediates iodide uptake in the thyroid gland.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors.

DISEASE:
Thyroid dyshormonogenesis 1 (TDH1) [MIM:274400]: A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Database links:

Entrez Gene: 6528 Human

Entrez Gene: 114613 Rat

Omim: 601843 Human

SwissProt: Q92911 Human

SwissProt: Q63008 Rat

Unigene: 103983 Human

Unigene: 584804 Human

Unigene: 10505 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

鈉/碘轉(zhuǎn)運(yùn)體蛋白-NIS,是位于甲狀腺細(xì)胞基底膜上的一類膜抗原,在甲狀腺對(duì)碘的主動(dòng)轉(zhuǎn)運(yùn)過程中發(fā)揮重要作用。
鈉/碘轉(zhuǎn)運(yùn)蛋白受甲狀腺刺激素(TSH)、碘、細(xì)胞因子和生長因子等多種因素的廣泛調(diào)節(jié)。自身免疫性甲狀腺疾病時(shí)NIS的表達(dá)發(fā)生了明顯變化,患者體內(nèi)出現(xiàn)抗NIS自身抗體。
此外,NIS還與甲狀腺冷結(jié)節(jié)和先天性甲狀腺機(jī)能減退等甲狀腺疾病的發(fā)病機(jī)理密切相關(guān),近年來得到了足夠的重視。
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