亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产又粗又猛又爽的视频国产,一本大道香蕉久在线播放看
Rabbit Anti-FBXO11/BF594 Conjugated antibody (bs-8472R-BF594)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-8472R-BF594
英文名稱 Rabbit Anti-FBXO11/BF594 Conjugated antibody
中文名稱 BF594標(biāo)記的F-box蛋白相關(guān)蛋白11抗體
別    名 F box protein 11; F-box only protein 11; FBX11; FBX11_HUMAN; Fbxo11; Fbxo 11; Fbxo-11; PRMT9; VIT-1; VIT1; Vitiligo associated protein VIT 1; Vitiligo-associated protein 1.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 104kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FBXO11
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the F-box protein familywhich is characterized by an approximately 40 amino acid motif, theF-box. The F-box proteins constitute one of the four subunits ofubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),which function in phosphorylation-dependent ubiquitination. TheF-box proteins are divided into 3 classes: Fbws containing WD-40domains, Fbls containing leucine-rich repeats, and Fbxs containingeither different protein-protein interaction modules or norecognizable motifs. The protein encoded by this gene belongs tothe Fbxs class. It can function as an arginine methyltransferasethat symmetrically dimethylates arginine residues, and it acts asan adaptor protein to mediate the neddylation of p53, which leadsto the suppression of p53 function. This gene is known to bedown-regulated in melanocytes from patients with vitiligo, a skindisorder that results in depigmentation. Polymorphisms in this geneare associated with chronic otitis media with effusion andrecurrent otitis media (COME/ROM), a hearing loss disorder, and theknockout of the homologous mouse gene results in the deaf mousemutant Jeff (Jf), a single gene model of otitis media.Alternatively spliced transcript variants encoding distinctisoforms have been identified for this gene. [provided by RefSeq,Jun 2010].

Function:
Substrate recognition component of the a(SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex whichmediates the ubiquitination and subsequent proteasomal degradationof target proteins. Probably recognizes and binds to phosphorylatedtarget proteins. Binds to and neddylates phosphorylated p53/TP53,inhibiting its transcriptional activity. SCF(FBXO11) does not seemto direct ubiquitination of TP53.

Subunit:
Component of the probable SCF(FBXWO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with TP53.

Subcellular Location:
Nucleus

Tissue Specificity:
Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.

Similarity:
Contains 1 F-box domain.
Contains 19 PbH1 repeats.
Contains 1 UBR-type zinc finger.

Database links:

Entrez Gene: 80204 Human

Entrez Gene: 225055 Mouse

Entrez Gene: 301674 Rat

Omim: 607871 Human

SwissProt: Q86XK2 Human

SwissProt: Q7TPD1 Mouse

SwissProt: Q7TSL3 Rat

Unigene: 352677 Human

Unigene: 386857 Mouse

Unigene: 36585 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
亚洲国产无线乱码在线观看 | 日韩亚洲人成在线 | 最近中文字幕国语免费高清6 | 国产精品自在在线免费 | 国产高清国内精品福利色噜噜 | 鲁人人人鲁人人鲁精品 | 久久99久国产精品黄毛片 | 狠狠精品干练久久久无码中文字幕 | 亚洲中文字幕在线第六区 | 亚洲国产精品一区二区三区在线观看 | 一本大道香蕉中文在线视频 | 日韩中文字幕无码R级电影 色婷婷AV一区二区三区在线观看 | 亚洲免费视频在线 | 热re99久久精品国99热 | 午夜欧美精品久久久久久久 | 精品日产1区2卡三卡麻豆 | 欧美日韩久久久精品A片 | 久久久久99狠狠综合久久 | 熟女自慰白浆一区二区 | 日本免费一区视频 | 国产成人精品无缓存在线播放 | 欧美激情欲高潮视频在线观看 | 精品无人区一区二区三区 | 亚洲欧美日韩一区二区在线观看 | 日本内射精品一区二区视频 | 国产午夜男女爽爽爽爽爽 | 国产亚洲色婷婷久久99精品 | 久久亚洲AV无码精品福利 | 2021国产精品视频一区 | 晓雪老师我要进你里面好爽 | AV天堂午夜精品一区二区三区 | 久久亚洲美日韩精品无码一区二区 | 日韩一区二区免费视频 | 麻豆果冻传媒新剧国产杜鹃 | 欧美一级一区二区中文字幕 | 亚洲成年网站在线观看 | 亚洲精品中文无码AV在线播放 | 91性高湖久久久久久久久 | 91精品国产色综合久久不卡美美 | 精品熟女碰碰人人A久久 | 超级乱淫小黄文小说 |