亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
激情综合激情五月俺也去,欧美a∨亚洲欧美亚洲
Rabbit Anti-ROCK1/Cy5 Conjugated antibody (bs-1166R-Cy5)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1166R-Cy5
英文名稱 Rabbit Anti-ROCK1/Cy5 Conjugated antibody
中文名稱 Cy5標(biāo)記的Rho相關(guān)蛋白激酶1抗體
別    名 p160 ROCK1; p160ROCK; Renal carcinoma antigen NY REN 35; Rho associated coiled coil containing protein kinase 1; Rho associated protein kinase 1; Rho-associated coiled-coil containing protein kinase 1; ROCK1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  激酶和磷酸酶  細(xì)胞骨架  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 158kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ROCK1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq].

Function:
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation.

Subunit:
Homodimer. Interacts with RHOB, RHOC, MYLC2B snd PTEN (By similarity). Interacts with RHOA (activated by GTP), CHORDC1, DAPK3, GEM, JIP3, RHOE, PPP1R12A, PFN1, LIMK1, LIMK2 and TSG101. Interacts with FHOD1 in a Src-dependent manner.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton, centrosome, centriole (By similarity). Golgi apparatus membrane; Peripheral membrane protein. Cell projection, bleb. Note=Associated with the mother centriole and an intercentriolar linker (By similarity). A small proportion is associated with Golgi membranes.

Tissue Specificity:
Detected in blood platelets.

Post-translational modifications:
Autophosphorylated on serine and threonine residues. Phosphorylated upon DNA damage, probably by ATM or ATR.
Cleaved by caspase-3 during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing.

Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 PH domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 protein kinase domain.
Contains 1 REM (Hr1) repeat.

Database links:

Entrez Gene: 6093 Human

Entrez Gene: 19877 Mouse

Entrez Gene: 81762 Rat

Omim: 601702 Human

SwissProt: Q8MIT6 Cow

SwissProt: Q13464 Human

SwissProt: P70335 Mouse

SwissProt: Q63644 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ROCK1也是絲/蘇氨基酸激酶的一種,可調(diào)節(jié)細(xì)胞因子,促進(jìn)平滑肌收縮和肌動(dòng)蛋白的形成,因此又稱:含有卷曲螺旋的蛋白激酶。目前主要用于腫瘤浸潤(rùn)、轉(zhuǎn)移方面的研究。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
黄色视频软件免费下载 | 亚1州区2区3区4区产品图片 | 在线视频一区二区三区四区 | 456亚洲人成影院在线观 | 免费在线视频一区 | 日韩青草青草久热精品视频在线网站乱码 | 高清一级毛片一本到免费观看 | 国产成A人亚洲精V品无码樱花 | 国产喷水1区2区3区咪咪爱AV | 国产精品高潮视亚洲乱码 | 日韩精品视频美在线精品视频 | 中文字幕在线观看亚洲日韩 | 真人短片20分钟以上 | 久久er热在这里只有精品66 到这里 | 性无码免费一区二区三区 | 亚洲精品ty久久久久久久久久 | 一区二区三区四区在线观看视频 | 青青草99久久精品国产综合 | 国产伦精品一区二区免费 | 亚洲精品高清视频在线观看 | 国产精品久久久久久福利 | 又大又粗又爽的少妇免费视频 | 国产麻豆天美果冻无码视频 | 亚洲精品无码a√中文字幕网站 | 丰满护士巨好爽好大乳小说 | 亚洲日本香蕉观看观视频 | 公交车掀开奶罩边躁狠狠躁视频 | 日韩欧美国产精品亚洲二区 | 国产又粗又黄又爽的大片 | 国产二级一片内射视频播放 | 日韩欧美一区二区三区免费观看 | 精品无码国产自产野外拍在线 | 九九精品免费观看在线 | 日韩免费中文字幕 | 国产全肉乱妇杂乱视频 | 色狠狠一区二区三区熟女91 | 国产成人91亚洲精品无码观看 | 91欧洲在线视精品在亚洲 | 欧美一级aa系列婷婷99 | 久久夜色撩人精品国产小说 | 中文字幕精品一区二区精品 |