亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
全黄H全肉短篇禁乱NP慕浅浅 ,欧美性猛交黑人粗大
Rabbit Anti-ROCK1/PE-Cy7 Conjugated antibody (bs-1166R-PE-Cy7)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1166R-PE-Cy7
英文名稱 Rabbit Anti-ROCK1/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標(biāo)記的Rho相關(guān)蛋白激酶1抗體
別    名 p160 ROCK1; p160ROCK; Renal carcinoma antigen NY REN 35; Rho associated coiled coil containing protein kinase 1; Rho associated protein kinase 1; Rho-associated coiled-coil containing protein kinase 1; ROCK1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  激酶和磷酸酶  細(xì)胞骨架  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 158kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ROCK1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq].

Function:
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation.

Subunit:
Homodimer. Interacts with RHOB, RHOC, MYLC2B snd PTEN (By similarity). Interacts with RHOA (activated by GTP), CHORDC1, DAPK3, GEM, JIP3, RHOE, PPP1R12A, PFN1, LIMK1, LIMK2 and TSG101. Interacts with FHOD1 in a Src-dependent manner.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton, centrosome, centriole (By similarity). Golgi apparatus membrane; Peripheral membrane protein. Cell projection, bleb. Note=Associated with the mother centriole and an intercentriolar linker (By similarity). A small proportion is associated with Golgi membranes.

Tissue Specificity:
Detected in blood platelets.

Post-translational modifications:
Autophosphorylated on serine and threonine residues. Phosphorylated upon DNA damage, probably by ATM or ATR.
Cleaved by caspase-3 during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing.

Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 PH domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 protein kinase domain.
Contains 1 REM (Hr1) repeat.

Database links:

Entrez Gene: 6093 Human

Entrez Gene: 19877 Mouse

Entrez Gene: 81762 Rat

Omim: 601702 Human

SwissProt: Q8MIT6 Cow

SwissProt: Q13464 Human

SwissProt: P70335 Mouse

SwissProt: Q63644 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ROCK1也是絲/蘇氨基酸激酶的一種,可調(diào)節(jié)細(xì)胞因子,促進(jìn)平滑肌收縮和肌動(dòng)蛋白的形成,因此又稱:含有卷曲螺旋的蛋白激酶。目前主要用于腫瘤浸潤(rùn)、轉(zhuǎn)移方面的研究。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
在线精品自偷自拍无码 | 国产精品免费一区二区区 | 亚洲揄拍窥拍久久国产自揄拍 | 久久国产免费一区二区三区 | 国产一级无码免费不卡| 疯狂做受xxxx高潮对白 | 老师好大乳好紧好深动态图 | 91色老久久精品偷偷蜜臀 | 欧美精品一区二区三区久久久精品 | 粉色视频午夜网站入口 | 国产色XX群视频射精 | 性欧美video另类hd尤物 | 国产日韩视频在线观看 | 久久aa毛片免费播放嗯啊 | 嫦娥仙子含精肉臀迎合 | 国产最新一区二区三区天堂 | 午夜美女福利视频 | 色欲久久精品亚洲AV无码一区 | 欧美精品大香伊蕉在人线 | 亚洲欧美日韩在线视频 | 狠狠精品干练久久久无码中文字幕 | 穿着白丝被强行侵犯漫画 | 快插我BB好爽舔我视频 | 亚洲国产精品国自产拍久久 | 波少野结衣色在线 | 无码一级a一片免费看 | 午夜尤物禁止18点击进入 | 国产精品亚洲AV毛片一区二区三区 | 国产美女一级做视频爱 | 精品极品三大极久久久久 | 榴莲视频在线看一日韩 | 国产精品视频一区国模私拍 | 2020天堂在线亚洲精品专区 | 国产精品欧美激情第一页 | 全黄裸片一29分钟免费真人版 | 80年代十大欧美成人片 | 日韩免费特黄特色大片 | 和上司交换娇妻在线播放 | 国内精品一级毛片免费看 | 午夜精品一区二区三区在线观看 | 五月丁香久久伊人本道开心 |