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Rabbit Anti-SGLT1/Cy5 Conjugated antibody (bs-1128R-Cy5)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1128R-Cy5
英文名稱 Rabbit Anti-SGLT1/Cy5 Conjugated antibody
中文名稱 Cy5標(biāo)記的鈉-糖共轉(zhuǎn)運(yùn)載體1抗體
別    名 D22S675; High affinity sodium glucose cotransporter 1; GLT1; GLT-1; High affinity sodium glucose cotransporter; Human Na+/glucose cotransporter 1; Na(+)/glucose cotransporter 1; NAGT; SGLT 1; SLC5A1; Sodium glucose cotransporter 1; Sodium/glucose cotransporter 1; Solute carrier family 5 (sodium/glucose cotransporter) member 1; Solute carrier family 5 member 1.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 神經(jīng)生物學(xué)  轉(zhuǎn)運(yùn)蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 73kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SGLT1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Function:
Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed mainly in intestine and kidney.

Post-translational modifications:
N-glycosylation is not necessary for the cotransporter function.

DISEASE:
Congenital glucose/galactose malabsorption (GGM) [MIM:606824]: Intestinal monosaccharide transporter deficiency. It is an autosomal recessive disorder manifesting itself within the first weeks of life. It is characterized by severe diarrhea and dehydration which are usually fatal unless glucose and galactose are eliminated from the diet. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Database links:

Entrez Gene: 6523 Human

Entrez Gene: 20537 Mouse

Entrez Gene: 397113 Pig

Entrez Gene: 25552 Rat

Omim: 182380 Human

SwissProt: P13866 Human

SwissProt: Q8C3K6 Mouse

SwissProt: P53790 Rat

Unigene: 1964 Human

Unigene: 25237 Mouse

Unigene: 10224 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

葡萄糖的跨膜轉(zhuǎn)運(yùn)主要是通過SGLT1結(jié)合1 mol葡萄糖,2 mol的Na+,形成Na+-載體-葡萄糖復(fù)合物,順Na+的濃度梯度進(jìn)入細(xì)胞.不同物種的SGLT1具有較高的同源性.
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