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Rabbit Anti-TPM2/Gold Conjugated antibody (bs-1243R-Gold)
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訂購QQ:  400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1243R-Gold
英文名稱 Rabbit Anti-TPM2/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的原肌球蛋白抗體
別    名 AMCD1; Beta tropomyosin muscle; BETA-TM; DA1; DA2B; EPITHELIAL TROPOMYOSIN; FIBROBLAST MUSCLE TYPE TROPOMYOSIN; MGC109519; NEM4; TM2; TMSB; TPM2; TROP-2; TROPOMYOSIN 2; Tropomyosin 2 (beta chain); TPM2_MOUSE; TPM2_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  細(xì)胞表面分子  細(xì)胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TPM2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Tropomyosin is a dimeric coiled coil protein that binds along the length of actin filaments. It is associated with the thin filaments of muscle cells and the microfilaments of nonmuscle cells. Chicken embryo fibroblasts (CEF) contain five isoforms of tropomyosin (a, b, 1, 2, and 3), identified as such by their different apparent molecular masses after separation by SDS-PAGE, but similar biochemical properties, such as resistance to heat and organic solvents, the ability to bind to F actin filaments, and the lack of proline and tryptophan.

Function:
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization.

Subunit:
Heterodimer of an alpha and a beta chain.

Subcellular Location:
Cytoplasm, cytoskeleton.

Tissue Specificity:
Present in primary breast cancer tissue, absent from normal breast tissue.

Post-translational modifications:
Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization.

DISEASE:
Nemaline myopathy 4 (NEM4) [MIM:609285]: A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. Nemaline myopathy type 4 presents from infancy to childhood with hypotonia and moderate-to-severe proximal weakness with minimal or no progression. Major motor milestones are delayed but independent ambulation is usually achieved, although a wheelchair may be needed in later life. Note=The disease is caused by mutations affecting the gene represented in this entry.
Arthrogryposis, distal, 1A (DA1A) [MIM:108120]: A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the tropomyosin family.

Database links:

Entrez Gene: 7169 Human

Entrez Gene: 22004 Mouse

Entrez Gene: 500450 Rat

Omim: 190990 Human

SwissProt: P07951 Human

SwissProt: P58774 Mouse

SwissProt: P58775 Rat

Unigene: 300772 Human

Unigene: 646 Mouse

Unigene: 17580 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Trop-2蛋白主要存在于細(xì)胞胞質(zhì)及表面, 它是絲裂原活化蛋白激酶(MAPK)通路的一個重要組成部,參與細(xì)胞生長、增殖、分化、死亡及細(xì)胞間的功能同步等多種生理過程.
Trop-2在很多常見的腫瘤上扮演著重要角色,其中包括乳腺癌、胃癌、結(jié)腸癌、肺癌、前列腺癌、胰腺癌和子宮癌,有學(xué)者認(rèn)為:Trop-2在孕期內(nèi)所具有的生殖功能可能意味著它同腫瘤的生長有關(guān)聯(lián)。
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