亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
欧美日韩中文字幕群交视频在线观看 ,麻豆一区二区在我观看
Rabbit Anti-phospho-CDKN1B (Thr157)/BF555 Conjugated antibody (bs-5228R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-5228R-BF555
英文名稱 Rabbit Anti-phospho-CDKN1B (Thr157)/BF555 Conjugated antibody
中文名稱 BF555標(biāo)記的磷酸化P27抗體/周期素依賴激酶抑制劑抗體
別    名 p27 KIP 1 (phospho T157); p-p27 KIP 1 (phospho T157); p27Kip1(Phospho-Thr157); p-p27Kip1(Thr157); p-p27Kip1(T157); CDN1B_HUMAN; AA408329; AI843786; Cdki1b; CDKN 1B; CDKN 4; CDKN1B; CDKN1B; CDKN4; CDKN4; Cyclin Dependent Kinase Inhibitor 1B; Cyclin Dependent Kinase Inhibitor 1B; Cyclin dependent kinase inhibitor p27; Cyclin dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor 1B (p27, Kip1); Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor p27 Kip1; KIP 1; KIP1; MEN1B; MEN4; OTTHUMP00000195098; OTTHUMP00000195099; p27; p27 Kip1; P27-like cyclin-dependent kinase inhibitor; P27KIP1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 免疫學(xué)  細(xì)胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Dog, Pig, Rabbit, Guinea Pig, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human CDKN1B around the phosphorylation site of Thr157 [PA(p-T)DD]
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq, Jul 2008]

Function:
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

Subunit:
Forms a ternary compex with CCNE1/CDK2/CDKN1B.

Subcellular Location:
Nucleus. Cytoplasm. Endosome. Nuclear and cytoplasmic in quiescent cells.

Tissue Specificity:
Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.

Post-translational modifications:
Phosphorylated; phosphorylation occurs on serine, threonine and tyrosine residues. Phosphorylation on Ser-10 is the major site of phosphorylation in resting cells, takes place at the G(0)-G(1) phase and leads to protein stability. Phosphorylation on other sites is greatly enhanced by mitogens, growth factors, cMYC and in certain cancer cell lines. The phosphorylated form found in the cytoplasm is inactivate. Phosphorylation on Thr-198 is required for interaction with 14-3-3 proteins. Phosphorylation on Thr-187, by CDK2 leads to protein ubiquitination and proteasomal degradation. Tyrosine phosphorylation promotes this process. Phosphorylation by PKB/AKT1 can be suppressed by LY294002, an inhibitor of the catalytic subunit of PI3K. Phosphorylation on Tyr-88 and Tyr-89 has no effect on binding CDK2, but is required for binding CDK4. Dephosphorylated on tyrosine residues by G-CSF.
Ubiquitinated; in the cytoplasm by the KPC complex (composed of RNF123/KPC1 and UBAC1/KPC2) and, in the nucleus, by SCF(SKP2). The latter requires prior phosphorylation on Thr-187. Ubiquitinated; by a TRIM21-containing SCF(SKP2)-like complex; leads to its degradation.

DISEASE:
Defects in CDKN1B are the cause of multiple endocrine neoplasia type 4 (MEN4) . Multiple endocrine neoplasia (MEN) syndromes are inherited cancer syndromes of the thyroid. MEN4 is a MEN-like syndrome with a phenotypic overlap of both MEN1 and MEN2.

Similarity:
Belongs to the CDI family.

Database links:

Entrez Gene: 1027 Human

Entrez Gene: 12576 Mouse

Entrez Gene: 83571 Rat

Omim: 600778 Human

SwissProt: P46527 Human

Unigene: 238990 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

P27蛋白是一種新發(fā)現(xiàn)的周期素依賴激酶抑制劑,屬于細(xì)胞周期的負(fù)性調(diào)控因子。P27基因及其產(chǎn)物的異常表達(dá)可能與某些腫瘤的發(fā)生、發(fā)展有著密切的關(guān)系。P27蛋白對細(xì)胞周期的調(diào)控及在腫瘤中發(fā)揮著很重要的作用。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
白丝乳交内射一二三区 | 二区久久久国产AV色 | 一级欧美一级日韩 | 欧美人成片免费看视频不卡 | 波多野42部无码喷潮在线 | 性一交一无一伦一精一品视频 | 精品久久久久久无码中文字幕动漫 | 欧美日韩无线码免费播放器 | 最新国产精品精品视频 | 欧美日韩国产一区二区三区地区 | 最新亚洲中文字幕一区在线 | 久久久久国产一级毛片高清版 | 九九热精品视频在线观看 | 精品国产乱码久久久久久浪潮 | 高清欧美一区二区三区 | 内射无码AV-区二区在线观看 | 两根撑到极致哭着求饶h | 国产AV电影区二区三区曰曰骚网 | WWW国产精品内射老熟女 | 国内精品久久久久久久小说 | 91亚洲精品无码久久久久 | 视频一区在线免费观看 | 国产精品久久久久久久久久 | 国产AV电影区二区三区曰曰骚网 | 国产一区二区三区在线看片 | 韩剧《空洞》在线观看 | 波多野结衣AV全免费观 | h嗯啊巨肉寝室男男bl | 你的欲梦裸身在线播放 | 日本在线精品视频观看 | 国产在线视频欧美一区二区三区 | 国产成人免费高清激情视频 | 性短视频在线观看免费不卡流畅 | 国产99在线a视频 | 涩里番app黄版网站 无限资源免费观看视频大全 | 原神乳液狂飙开襟网站MIMEI | 级R片内射在线视频播放 | 欧美特级午夜一区二区三区 | 91视频一区二区三区 | 久久人人妻人人爽人人爽 | 999国内精品永久免费视频 |