亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
www.91视频.com,13小箩利无码视频网站免费
Rabbit Anti-phospho-CDKN1B (Thr157)/PE-Cy7 Conjugated antibody (bs-5228R-PE-Cy7)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-5228R-PE-Cy7
英文名稱 Rabbit Anti-phospho-CDKN1B (Thr157)/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標(biāo)記的磷酸化P27抗體/周期素依賴激酶抑制劑抗體
別    名 p27 KIP 1 (phospho T157); p-p27 KIP 1 (phospho T157); p27Kip1(Phospho-Thr157); p-p27Kip1(Thr157); p-p27Kip1(T157); CDN1B_HUMAN; AA408329; AI843786; Cdki1b; CDKN 1B; CDKN 4; CDKN1B; CDKN1B; CDKN4; CDKN4; Cyclin Dependent Kinase Inhibitor 1B; Cyclin Dependent Kinase Inhibitor 1B; Cyclin dependent kinase inhibitor p27; Cyclin dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor 1B (p27, Kip1); Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor p27 Kip1; KIP 1; KIP1; MEN1B; MEN4; OTTHUMP00000195098; OTTHUMP00000195099; p27; p27 Kip1; P27-like cyclin-dependent kinase inhibitor; P27KIP1.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
產(chǎn)品類(lèi)型 磷酸化抗體 
研究領(lǐng)域 免疫學(xué)  細(xì)胞周期蛋白  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Dog, Pig, Rabbit, Guinea Pig, )
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human CDKN1B around the phosphorylation site of Thr157 [PA(p-T)DD]
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq, Jul 2008]

Function:
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

Subunit:
Forms a ternary compex with CCNE1/CDK2/CDKN1B.

Subcellular Location:
Nucleus. Cytoplasm. Endosome. Nuclear and cytoplasmic in quiescent cells.

Tissue Specificity:
Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.

Post-translational modifications:
Phosphorylated; phosphorylation occurs on serine, threonine and tyrosine residues. Phosphorylation on Ser-10 is the major site of phosphorylation in resting cells, takes place at the G(0)-G(1) phase and leads to protein stability. Phosphorylation on other sites is greatly enhanced by mitogens, growth factors, cMYC and in certain cancer cell lines. The phosphorylated form found in the cytoplasm is inactivate. Phosphorylation on Thr-198 is required for interaction with 14-3-3 proteins. Phosphorylation on Thr-187, by CDK2 leads to protein ubiquitination and proteasomal degradation. Tyrosine phosphorylation promotes this process. Phosphorylation by PKB/AKT1 can be suppressed by LY294002, an inhibitor of the catalytic subunit of PI3K. Phosphorylation on Tyr-88 and Tyr-89 has no effect on binding CDK2, but is required for binding CDK4. Dephosphorylated on tyrosine residues by G-CSF.
Ubiquitinated; in the cytoplasm by the KPC complex (composed of RNF123/KPC1 and UBAC1/KPC2) and, in the nucleus, by SCF(SKP2). The latter requires prior phosphorylation on Thr-187. Ubiquitinated; by a TRIM21-containing SCF(SKP2)-like complex; leads to its degradation.

DISEASE:
Defects in CDKN1B are the cause of multiple endocrine neoplasia type 4 (MEN4) . Multiple endocrine neoplasia (MEN) syndromes are inherited cancer syndromes of the thyroid. MEN4 is a MEN-like syndrome with a phenotypic overlap of both MEN1 and MEN2.

Similarity:
Belongs to the CDI family.

Database links:

Entrez Gene: 1027 Human

Entrez Gene: 12576 Mouse

Entrez Gene: 83571 Rat

Omim: 600778 Human

SwissProt: P46527 Human

Unigene: 238990 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

P27蛋白是一種新發(fā)現(xiàn)的周期素依賴激酶抑制劑,屬于細(xì)胞周期的負(fù)性調(diào)控因子。P27基因及其產(chǎn)物的異常表達(dá)可能與某些腫瘤的發(fā)生、發(fā)展有著密切的關(guān)系。P27蛋白對(duì)細(xì)胞周期的調(diào)控及在腫瘤中發(fā)揮著很重要的作用。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
成人免费视频一区 | 亚洲免费视频在线 | 91精品国产无码高清 | 成年网站免费视频A在线双飞 | 国产高颜值大学生情侣酒店 | 亚洲第一区二区快射影院 | 亚洲AV无码久久精品国产 | 精品亚洲AV无码喷奶水在线观看 | 少妇的奶头又大又红又涨 | 久久久国产精品综合无人区 | 国产免费久久久久久久无码浪潮 | 一区二区乱子伦在线播放 | 欧美激情成a人在线观看 | 色综合久久综合网欧美综合网 | 免费看日产一区二区三区 | 久久久精品中文字幕麻豆发布 | 色欲精品久久人妻av中文字幕 | 激情欧美日韩一区二区 | 日本理伦片午夜理伦片 | 国产东北三老头伦一肥婆 | 18禁国产精品久久久久久久久 | 中韩高清无专码区2021曰 | 精品人妻中文字幕在线 | 国产精品永久免费视频观看 | 国产精品国产三级国产AV剧情 | 国产成A人亚洲精V品无码樱花 | 最近韩国日本免费观看MV免费版 | 性xxxxbbbb免费播放视频 | 亚洲AV无码黄 在线观看 | 九九在线精品视频 | 强行挺进美艳老师的后臀 | 国产一区二区精品久久岳√久久 | 久久人人爽人人爽人人片AV浪潮 | **色毛片免费观看 | 欧美午夜精品一区二区蜜桃 | 亚洲国产欧美目韩成人综合 | 国产真实老熟女无套内射 | 日韩欧美一区二区三区在线视频 | 国产性生大片免费观看性 | 中文字幕久久精品无码综合网 | 国产精品久久久久久久久久影院 |