亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
91麻豆成人精品国产免费网站,男女后进式猛烈XX00动态图片
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-phospho-E2F1 (Ser337)/PE-Cy5 Conjugated antibody (bs-5305R-PE-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-5305R-PE-Cy5
英文名稱 Rabbit Anti-phospho-E2F1 (Ser337)/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標記的磷酸化轉(zhuǎn)錄因子E2F-1抗體
別    名 phospho-E2F1(Ser337); p-E2F1 (phospho-Ser337); E2F1 (phospho S337); E2F 1; E2F transcription factor 1; E2F-1; E2f1 E2F transcription factor 1; KIAA4009; mKIAA4009; OTTHUMP00000030661; PBR 3; PBR3; PRB binding protein E2F 1; PRB-binding protein E2F-1; RBAP 1; RBAP-1; RBAP1; RBBP 3; RBBP-3; RBBP3; RBP 3; RBP3; Retinoblastoma associated protein 1; Retinoblastoma binding protein 3; Retinoblastoma-associated protein 1; Retinoblastoma-binding protein 3; Transcription factor E2F1; E2F1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Horse, )
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human E2F1 around the phosphorylation site of Ser337
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
E2F's are DNA binding proteins, which associate with negative regulators, such as the retinoblastoma p107 protein, resulting in an altered rate of gene transcription. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. E2F1 is proposed to be involved in several cellular processes that range from tumor suppressor, cell progression and oncogenesis. E2F1 overexpression can also drive cells into apoptosis.

Function:
Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis.

Subunit:
Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F-1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Binds TOPBP1. Interacts with ARID3A (By similarity). Binds EAPP.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase (By similarity).

Similarity:
Belongs to the E2F/DP family.

Database links:

Entrez Gene: 1869 Human

Omim: 189971 Human

SwissProt: Q01094 Human

Unigene: 654393 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

E2F1—屬于調(diào)節(jié)性轉(zhuǎn)錄因子E2F家族。有學(xué)者認為:E2F-1既可作為癌基因起作用,又可作為抑癌基因起作用。其不同可能由細胞中其他生長促進或抑制性蛋白質(zhì)水平和(或)活性決定,同時與細胞所處環(huán)境及器官特異性有關(guān)。在控制細胞周期和腫瘤抑制基因蛋白的活性方面起關(guān)鍵作用。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产成+人+综合+欧美亚洲 | 亚洲黄色一级大片 | 亚洲 日韩 丝袜 熟女 变态 | 国产免费人成视频网站在线18 | 老头埋进校花里面使劲添 | 国产成人精品美女在线 | 亚洲国产香蕉视频欧美 | 免费一级欧美片在线观 | 亚洲欧洲性色精品一区二区三区在线观看 | 久久99蜜桃精品久久久久 | 超碰国产精品人人做人人爱 | 天海翼一区二区三区四区 | 亚洲国产欧美日韩成人综合 | 蜜桃臀无码内射一区二区三区 | 91精品国产制服啪啪无码 | 人妻欧美精品AAAAAAAAA片 | 少妇被又大又粗又爽毛片久久黑人 | 精品国产乱码欠欠欠欠精品 | 亚洲欧美一区二区三区图片 | 欧美激情性A片视频播放 | 亚洲国产中文美日韩欧美特级 | 国产精品日本不卡一区二区 | 国产麻豆精品精东影业AV网站 | 又黑又粗大棒插白妇口视频 | 亚洲国产成人在线视频 | 2020精品国产自在现线官网 | 久久综合久久一区二区 | 在线观看亚洲AV无码每日更新 | 日本XXXXX黄区免费看下载 | 亚洲精品毛片永久播放 | 热久久国产欧美一区二区精品 | 女人高潮爽到全身痉挛抽搐 | 宝贝儿乖我们继续H | 999精品视频这里只有精品 | 免费观看精品国产污污污网站 | 精品久久久久成人码免费动漫 | 久久AV喷潮久久AV高 | 国产婷婷色综合AV蜜臀AV | 久久综合经典国产二区无码 | 色综合久久综合网欧美综合网 | 国产精品白浆无码流出AV动漫 |