亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
性满足BBWBBWBBW,欧美精品九九99久久在观看,亚洲日韩在线中文字幕一区
Rabbit Anti-phospho-E2F1 (Ser332)/PE Conjugated antibody (bs-5306R-PE)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-5306R-PE
英文名稱 Rabbit Anti-phospho-E2F1 (Ser332)/PE Conjugated antibody
中文名稱 PE標(biāo)記的磷酸化轉(zhuǎn)錄因子E2F-1抗體
別    名 phospho-E2F1(Ser332); p-E2F1 (phospho-Ser332); E2F1 (phospho S332); E2F 1; E2F transcription factor 1; E2F-1; E2f1 E2F transcription factor 1; KIAA4009; mKIAA4009; OTTHUMP00000030661; PBR 3; PBR3; PRB binding protein E2F 1; PRB-binding protein E2F-1; RBAP 1; RBAP-1; RBAP1; RBBP 3; RBBP-3; RBBP3; RBP 3; RBP3; Retinoblastoma associated protein 1; Retinoblastoma binding protein 3; Retinoblastoma-associated protein 1; Retinoblastoma-binding protein 3; Transcription factor E2F1; E2F1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
產(chǎn)品類(lèi)型 磷酸化抗體 
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse, 
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human E2F1 around the phosphorylation site of Ser332
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
E2F's are DNA binding proteins, which associate with negative regulators, such as the retinoblastoma p107 protein, resulting in an altered rate of gene transcription. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. E2F1 is proposed to be involved in several cellular processes that range from tumor suppressor, cell progression and oncogenesis. E2F1 overexpression can also drive cells into apoptosis.

Function:
Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis.

Subunit:
Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F-1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Binds TOPBP1. Interacts with ARID3A. Binds EAPP.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase.

Similarity:
Belongs to the E2F/DP family.

Database links:

Entrez Gene: 1869 Human

Omim: 189971 Human

SwissProt: Q01094 Human

Unigene: 654393 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

E2F1—屬于調(diào)節(jié)性轉(zhuǎn)錄因子E2F家族。有學(xué)者認(rèn)為:E2F-1既可作為癌基因起作用,又可作為抑癌基因起作用。其不同可能由細(xì)胞中其他生長(zhǎng)促進(jìn)或抑制性蛋白質(zhì)水平和(或)活性決定,同時(shí)與細(xì)胞所處環(huán)境及器官特異性有關(guān)。在控制細(xì)胞周期和腫瘤抑制基因蛋白的活性方面起關(guān)鍵作用。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
国产精品秘 麻豆果冻传媒沈娜娜 | 国产素人在线观看人成视频 | 内射中出无码护士在线 | 二级毛片在线观看 | 久久国产精品自线拍免费 | 中国国语毛片免费观看视频 | 午夜精品成人一区二区视频 | 中国一级毛片在线观看 | 蜜臀亚洲AV永久无码精品老司机 | 456性欧美在线视频 玩弄放荡人妻一区二区三区 | 任我鲁精品视频精品 | 情侣网站大黄网站 | 国产成人综合亚洲欧美在线观看 | 亚洲精品嫩草研究院久久 | 老师你夹得好紧好爽动态图 | BGMBGMBGM黑人极品 | 久久久久无码精品黑人 | 欧美日韩国产综合视频在线观看 | 欧洲性开放大片免费观看视频 | 久久无码人妻精品一区二区三区 | 天天摸夜夜躁躁到高潮av | 国产真实乱对白精彩 | 久久综合九色综合欧美久久久 | 久久精品无码鲁网中文电影 | 欧美一级高清AAA片免费观看 | 久久久无码人妻精品无码 | 欧洲美女高清一级毛片 | 日本一区二区三区在线网 | 好大水好多别射在里面H | 99久久免费精品高清特色大片 | 动漫精品中文无码卡通动漫 | 欧美激情综合色综合啪啪五月 | 日本三级欧美三级 | 国产乱来乱子视频 | 91桃色污无限免费看 | 苍井空毛片精品久久久 | VR虚拟专区亚洲精品二区 | 2019国产在线我不卡香蕉 | 一级成人欧美一区在线观看 | 午夜性色一区二区三区不卡视频 | 胸大美女又黄的网站 |