亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
美女视频黄a视频全免费网站色窝,亚洲色欲色欲77777小说
Rabbit Anti-phospho-E2F1 (Ser332)/PE-Cy5 Conjugated antibody (bs-5306R-PE-Cy5)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-5306R-PE-Cy5
英文名稱 Rabbit Anti-phospho-E2F1 (Ser332)/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標(biāo)記的磷酸化轉(zhuǎn)錄因子E2F-1抗體
別    名 phospho-E2F1(Ser332); p-E2F1 (phospho-Ser332); E2F1 (phospho S332); E2F 1; E2F transcription factor 1; E2F-1; E2f1 E2F transcription factor 1; KIAA4009; mKIAA4009; OTTHUMP00000030661; PBR 3; PBR3; PRB binding protein E2F 1; PRB-binding protein E2F-1; RBAP 1; RBAP-1; RBAP1; RBBP 3; RBBP-3; RBBP3; RBP 3; RBP3; Retinoblastoma associated protein 1; Retinoblastoma binding protein 3; Retinoblastoma-associated protein 1; Retinoblastoma-binding protein 3; Transcription factor E2F1; E2F1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, 
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human E2F1 around the phosphorylation site of Ser332
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
E2F's are DNA binding proteins, which associate with negative regulators, such as the retinoblastoma p107 protein, resulting in an altered rate of gene transcription. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. E2F1 is proposed to be involved in several cellular processes that range from tumor suppressor, cell progression and oncogenesis. E2F1 overexpression can also drive cells into apoptosis.

Function:
Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis.

Subunit:
Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F-1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Binds TOPBP1. Interacts with ARID3A. Binds EAPP.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase.

Similarity:
Belongs to the E2F/DP family.

Database links:

Entrez Gene: 1869 Human

Omim: 189971 Human

SwissProt: Q01094 Human

Unigene: 654393 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

E2F1—屬于調(diào)節(jié)性轉(zhuǎn)錄因子E2F家族。有學(xué)者認(rèn)為:E2F-1既可作為癌基因起作用,又可作為抑癌基因起作用。其不同可能由細(xì)胞中其他生長(zhǎng)促進(jìn)或抑制性蛋白質(zhì)水平和(或)活性決定,同時(shí)與細(xì)胞所處環(huán)境及器官特異性有關(guān)。在控制細(xì)胞周期和腫瘤抑制基因蛋白的活性方面起關(guān)鍵作用。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
亚洲激情无码一区二区三区 | www.一级片.com| 欧美综合区自拍亚洲综合天堂 | 狼人香蕉香蕉在线28 | 很狠干线观看2021 | 囯产精品一品二区三区 | 中文字幕在线成人免费看 | 99re久久在热线播放最新地址 | 成人国产一区二区精品小说 | 亚洲va国产日韩欧美精品 | 国产乱人伦AV麻豆网 | 嫩草在线视频WWW免费看 | 久久精品国产9久久综合 | 黄片视频在线免费观看 | 强行无套内大学生初次 | 久久99精品国产99久久6尤物 | 国产精品一区二区三区免费 | 极品尤物喷水爆白浆呻吟小说 | 欧美日韩精品一区二区在线播放蜜臀 | 国产精品99久久久久久WWW | 亚洲 校园 欧美 国产 另类 | 亚洲成a人v欧美综合天堂下载 | 免费A级毛片—亚洲一区二区久久69 | 日韩一进一出免费试频 | 精品一区二区三区免费观看 | 宝贝儿乖我们继续H | 欧美特黄特黄免费三级视频 | 一二三四中文字幕 | 日韩久久精品无码一二级 | 少妇被躁爽到高潮无码人狍大战 | 亚洲精品一二三区尤物tv | 七姐妹在线观看免费播放国语 | 香蕉苹果水蜜桃丝瓜视频 | 最近免费中文字幕大全高清大全10 | 亚洲国产一区二区精品专区发布 | 日韩欧美精品在线观看 | 国产婷婷色一区二区三区在线 | 中文无码精品一区二区三区 | 久久线看在观草草青青脱裤 | 免费无码专区毛片高潮喷水 | 丝袜美腿国产综合久久 |