亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
一区二区高清无码电影,精品无码乱码AV,ww男人的天堂视频在线观看
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-GIT1/Cy7 Conjugated antibody (bs-4110R-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-4110R-Cy7
英文名稱 Rabbit Anti-GIT1/Cy7 Conjugated antibody
中文名稱 Cy7標記的G蛋白偶聯(lián)受體激酶相互作用蛋白1抗體
別    名 ARF GAP GIT1; ARF GTPase activating protein GIT1; CAT 1; Cat1; Cool associated and tyrosine phosphorylated protein 1; G protein coupled receptor kinase interactor 1; GRK interacting protein 1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學  轉(zhuǎn)錄調(diào)節(jié)因子  G蛋白偶聯(lián)受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 84kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GIT1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5).

Function:
GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes.

Subcellular Location:
Cytoplasm. Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes towards the leading edge, while, when cells adhere, it is found in vinculin-containing adhesions. Recruitment to adhesions may be mediated by active tyrosine-phosphorylated paxillin.

Post-translational modifications:
Phosphorylated on tyrosine residues by PTK2 and SRC in growing fibroblasts. Tyrosine-phosphorylation is increased following cell spreading on fibronectin, decreased in cells arrested in mitosis and increased in the ensuing G1 phase.

Similarity:
Contains 3 ANK repeats.
Contains 1 Arf-GAP domain.

Database links:

Entrez Gene: 28964 Human

Entrez Gene: 216963 Mouse

Entrez Gene: 83709 Rat

Omim: 608434 Human

SwissProt: Q9Y2X7 Human

SwissProt: Q68FF6 Mouse

SwissProt: Q9Z272 Rat

Unigene: 514051 Human

Unigene: 290182 Mouse

Unigene: 34521 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国内毛片毛片毛片毛片毛片毛片毛片毛片毛片毛片毛片毛片 | 亚洲AV无码成人精品区东京热 | 全肉野战高h含苞欲 | 成人精品天堂一区二区三区 | 老汉扛起娇妻玉腿进入 | 日产精品美女久久久网站大全 | 一本色道久久a久久精品综合网站免费 | 九热这里只有精品 | 无码毛片内射白浆视频 | 一本大道香蕉高清久久 | 久久久久无码精品黑人 | 91国内揄拍国内精品对白不卡 | 亚洲精品在线免费 | 周妍希裸乳图片无遮挡 | 亚洲国产精品人人做人人爽 | 国产激情无码久久久久久 | 无码国产亚洲日韩国精品视频一区二区三区 | 777米奇影视第四色 人人看人人摸人人操637 | 亚洲精品国品乱码久久久久 | 中出人妻中文字幕无码 | 亚洲一区爱区精品无码 | 九九线精品视频在线观看视频 | 免费被黄动漫网站在线无网观看 | 粗大的内捧猛烈进出视频网 | 直接在线观看的三级网址 | 黄区1区2区3区4区5区 | 精品一区二区久久久久久久网精 | 在线免费观看日韩视频 | 国产精品亚洲av综合成久久久久久三级 | 成人国产精品日本在线 | 亚洲精品动漫免费二区 | 456亚洲人成在线播放网站 | 91热久久免费频精品黑人99 | 丰满人妻少妇久久久久久 | 中文天堂网在线最新版 | 99久久国产宗和精品1上映 | 国产精品青青青高清在线 | 成人网站www污污污网站 | 无人视频在线观看完整版高清视频 | 国产又黄又硬又粗 | 国产素人在线观看人成视频 |