亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
亚洲人妻少妇av资源网站,亚洲精品成A人在线观看,人人揉人人捏人人爽五月天
Rabbit Anti-GIT1/PE-Cy3 Conjugated antibody (bs-4110R-PE-Cy3)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-4110R-PE-Cy3
英文名稱 Rabbit Anti-GIT1/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標(biāo)記的G蛋白偶聯(lián)受體激酶相互作用蛋白1抗體
別    名 ARF GAP GIT1; ARF GTPase activating protein GIT1; CAT 1; Cat1; Cool associated and tyrosine phosphorylated protein 1; G protein coupled receptor kinase interactor 1; GRK interacting protein 1.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  G蛋白偶聯(lián)受體  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 84kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GIT1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5).

Function:
GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes.

Subcellular Location:
Cytoplasm. Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes towards the leading edge, while, when cells adhere, it is found in vinculin-containing adhesions. Recruitment to adhesions may be mediated by active tyrosine-phosphorylated paxillin.

Post-translational modifications:
Phosphorylated on tyrosine residues by PTK2 and SRC in growing fibroblasts. Tyrosine-phosphorylation is increased following cell spreading on fibronectin, decreased in cells arrested in mitosis and increased in the ensuing G1 phase.

Similarity:
Contains 3 ANK repeats.
Contains 1 Arf-GAP domain.

Database links:

Entrez Gene: 28964 Human

Entrez Gene: 216963 Mouse

Entrez Gene: 83709 Rat

Omim: 608434 Human

SwissProt: Q9Y2X7 Human

SwissProt: Q68FF6 Mouse

SwissProt: Q9Z272 Rat

Unigene: 514051 Human

Unigene: 290182 Mouse

Unigene: 34521 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
日本电影亚洲欧美精品素人 | 中文字幕一区二区在线观看 | 每日更新在线观看av | 国产成人一区免费观看 | 午夜尤物禁止18点击进入 | 亚洲欧美国产成人综合不卡 | 国产精品99久久久久久WWW | 精品国产一区二区三区久久影院 | 亚洲色欲色欲WWW在线丝 | 无码精品人妻一区二区三区免费 | 日本一二三不卡视频 | 国产精品xxxav免费视频 | 亚洲va国产日韩欧美精品 | 国产日产欧产精品精品 | 亚洲国产一区二区三区AV | 亚洲日韩在线中文字幕一区 | 久久久精品无码一二三区 | 欧美人妻中文字幕乱码在线 | AV无码久久久久不卡网站毛片 | 重口SM一区二区三区视频 | 日本韩国的免费观看视频 | 中文字幕精品一区二区精品 | 中文字幕无码精品久久久 | 久久婷婷97人妻无码狠狠综合久久久久综合 | 亚洲精品白浆高清久久久久久 | 国产成人精品123区免费视频 | 久久人做人爽一区二区三区 | 久久人人爽人人人人片 | 97精品国产高清在线看入口 | 亚洲AV无码专区在线观看在线 | 给个网站2021年直接进入的 | 九九在线中文字幕无码 | 国产又猛又黄又爽 | 亚洲v无码专区国产乱码一区二区 | 亚洲中文字幕每日更新 | 中文字幕日韩一区二区不卡 | 亚洲精品无码高潮喷水在 | 最近2019中文字幕免费直播 | 亚洲精品一二三区尤物tv | 国产精品伦一区二区三级视频 | 色偷偷亚洲第一综合网 |