亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
国产高潮大合集抽搐不止,96视频人澡人澡日日,国产美女久久久久久久久久久
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-GIT1/APC Conjugated antibody (bs-4110R-APC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-4110R-APC
英文名稱 Rabbit Anti-GIT1/APC Conjugated antibody
中文名稱 APC標記的G蛋白偶聯(lián)受體激酶相互作用蛋白1抗體
別    名 ARF GAP GIT1; ARF GTPase activating protein GIT1; CAT 1; Cat1; Cool associated and tyrosine phosphorylated protein 1; G protein coupled receptor kinase interactor 1; GRK interacting protein 1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  免疫學  轉錄調(diào)節(jié)因子  G蛋白偶聯(lián)受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, )
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 84kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GIT1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5).

Function:
GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes.

Subcellular Location:
Cytoplasm. Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes towards the leading edge, while, when cells adhere, it is found in vinculin-containing adhesions. Recruitment to adhesions may be mediated by active tyrosine-phosphorylated paxillin.

Post-translational modifications:
Phosphorylated on tyrosine residues by PTK2 and SRC in growing fibroblasts. Tyrosine-phosphorylation is increased following cell spreading on fibronectin, decreased in cells arrested in mitosis and increased in the ensuing G1 phase.

Similarity:
Contains 3 ANK repeats.
Contains 1 Arf-GAP domain.

Database links:

Entrez Gene: 28964 Human

Entrez Gene: 216963 Mouse

Entrez Gene: 83709 Rat

Omim: 608434 Human

SwissProt: Q9Y2X7 Human

SwissProt: Q68FF6 Mouse

SwissProt: Q9Z272 Rat

Unigene: 514051 Human

Unigene: 290182 Mouse

Unigene: 34521 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
嗯~啊~快点死我女女 | 日本产品和韩国产品哪个好99 | 图片区乱熟图片区小说 | 日本丰满护士BBW | 18视频入口网站在线看 | 国产91无毒不卡在线观看 | 国产一区二区精品久久岳√久久 | 亚洲AV成人男人的天堂网 | 成人精品天堂一区二区三区 | 胸大美女又黄的网站 | 亚洲 校园 欧美 国产 另类 | 欧洲精品A片一区二区免费 国产乱老熟视频乱老熟女51 | 国产黑丝一区二区 | 国产精品久久久久久福利 | 国产精品一区二区不卡的视频 | 成人看片黄a在线看 | 欧美手机手机在线视频一区 | 日韩久久免费影院观看 | 一区二区高清无码电影 | 爆乳3把你榨干哦OVA在线观看 | 精品21国产成人综合网在线 | 香港日本三级在线播放 | 欧美又大粗又爽又黄大片视频 | 66亚洲一卡2卡新区成片发布 | 囯产精品一区二区三区线 | 国产精品久久久久久亚洲小说 | 黄色毛片在线观看 | 在线观看日本污污ww网站 | 国产精品亚欧美一区二区三区 | 好紧好爽好疼的免费视频全集完整版在线播放 | 91麻豆成人精品国产免费网站 | 久久久久久久Aⅴ无码免费网站 | a级毛片免费全部播放无码 日韩久久久久精品一区二区三区 | 麻豆传播媒体免费版官网 | 国产精品亚洲二线在线播放 | 爱呦视频在线播放网址 | 2012中文字幕一页免费 | 色伦专区97中文字幕 | 肥熟老熟妇500部视频 | 爽死你个放荡粗暴小淫货漫画 | 伊人久久综合精品无码av专区 |