亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢(xún)技術(shù)支持           掃碼咨詢(xún)技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
亚洲和欧洲一码二码区别7777,又黄又湿真实网站不付费,一本AV高清一区二区三区
Rabbit Anti-phospho-IGF1R (Tyr1165 + Tyr1166)/Gold Conjugated antibody (bs-5449R-Gold)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-5449R-Gold
英文名稱(chēng) Rabbit Anti-phospho-IGF1R (Tyr1165 + Tyr1166)/Gold Conjugated antibody
中文名稱(chēng) 膠體金標(biāo)記的磷酸化胰島素樣生長(zhǎng)因子1受體抗體
別    名 IGF1 Receptor (phospho Y1165 + Y1166); p-IGF1 Receptor (phospho Y1165 + Y1166); IGF-1R (Phospho-Tyr1165/Tyr1166); IGF1R (phospho Y1165+Y1166); IGF1R (phospho Tyr1165+Tyr1166); p-IGF1R (Tyr1165+Tyr1166); phospho-IGF1R (Tyr1166+Tyr1167)rat; phospho-IGF1R (Tyr1166+Tyr1167)mo; CD221; CD221 antigen; IGF 1 receptor; IGF 1R; IGF I receptor; IGF1R; IGFIR; IGFIRC; Insulin like growth factor 1 receptor; Insulin like growth factor 1 receptor precursor; JTK13; MGC142170; MGC142172; IGF1 Receptor; IGF1R_HUMAN; IGF-IR.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul(10nm  15nm  35nm
產(chǎn)品類(lèi)型 磷酸化抗體 
研究領(lǐng)域 信號(hào)轉(zhuǎn)導(dǎo)  生長(zhǎng)因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  細(xì)胞膜受體  糖尿病  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 150kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human IGF1R around the phosphorylation site of Tyr1165+Tyr1166
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008].

Function:
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

Subunit:
Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Forms a hybrid receptor with INSR, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with ARRB1 and ARRB2.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibrobasts, spleen and placenta (at protein level). Expressed in a variety of tissues.

Post-translational modifications:
The cytoplasmic domain of the beta subunit is autophosphorylated on tyrosine residues in response to insulin-like growth factor I (IGF I).
Phosphorylation of Tyr-980 is required for IRS1- and SHC1-binding.

DISEASE:
Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance) [MIM:270450]. IGF1 resistance is a gowth deficiency disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Contains 3 fibronectin type-III domains.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 3480 Human

Entrez Gene: 16001 Mouse

Entrez Gene: 25718 Rat

Omim: 147370 Human

SwissProt: P08069 Human

SwissProt: Q60751 Mouse

SwissProt: P24062 Rat

Unigene: 643120 Human

Unigene: 714012 Human

Unigene: 275742 Mouse

Unigene: 10957 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
国产精品视频第一区二区三区 | 国产91av在线播放网站 | 一级毛片免费视频网站 | 一本一道久久a久久综合蜜桃 | 日本在线视频一区 | 最近高清中文字幕免费MV | 国内精品久久久久久久试看 | 免费国产黄线在线播放 | 六月婷婷国产精品综合 | 熟女国产精品视频一区二区三区 | 国内精品久久久久久久小说 | 免费无毒a网站在线观看 | 夜里十大禁用短视频软件 | 少妇又紧又色又爽又刺激视频 | 亚洲一区在线播放 | 最近中文在线字幕在线观看 | 最近的中文字幕在线MV视频 | 一级做a爰片久久毛片免费陪 | 综合一区无套内射中文字幕 | 粉嫩大学生无套内射无码专区久久 | 中文字幕在线视频一区 | 亚洲成人av综合久久久蜜桃臀 | 精品一卡2卡三卡4卡乱码毛1 | 国产精品老熟女视频一区二区 | 欧美日韩精品视频一区二区三区在线观看 | 深夜久久AAAAA级毛片免费看 | 婷婷久久综合九色综合伊人色 | 欧美日韩一区精品高免费专区 | 国产-第1页-浮力影院 | 91日本在线观看亚洲精品 | 国产日韩精品一区二区在线观看 | 不卡在线播放一区二区三区 | 麻豆日产精品卡2卡3卡4卡5卡 | 精品国产乱码久久久久久久小说 | 在线观看午夜亚洲一区 | 无码一级a一片免费看 | 中文字幕亚洲综合久久菠萝蜜 | 精品国产福利一区二区在线 | 亚洲精品国产第一综合99久久 | 国产综合精品久久久久成人影 | 最火的app排行榜前十名 |