亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
综合一区二区自拍亚洲,国产内射老熟女AAAA㏄ww
Rabbit Anti-VAV1/PE-Cy5 Conjugated antibody (bs-4167R-PE-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-4167R-PE-Cy5
英文名稱 Rabbit Anti-VAV1/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標(biāo)記的鳥苷酸轉(zhuǎn)換因子VAV1抗體
別    名 Oncogene vav; p95Vav; Protooncogene vav; Proto-oncogene vav; VAV 1; VAV 1 oncogene; VAV; Vav proto oncogene; Vav proto-oncogene; VAV_HUMAN; VAV1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  染色質(zhì)和核信號  信號轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  G蛋白偶聯(lián)受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 98kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human VAV1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012].

Function:
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

Subunit:
May interact with CCPG1. Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. Interacts with SHB and CLNK. Interacts with THEMIS2. Interacts with HCK. Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with ITK. Interacts with PTK2B/PYK2. Interacts (via SH2 domain) with SYK. Interacts with ANKRD54.

Tissue Specificity:
Widely expressed in hematopoietic cells but not in other cell types.

Post-translational modifications:
Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS). Phosphorylated by FYN.

Similarity:
Contains 1 CH (calponin-homology) domain.
Contains 1 DH (DBL-homology) domain.
Contains 1 PH domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 SH2 domain.
Contains 2 SH3 domains.

Database links:

Entrez Gene: 7409 Human

Entrez Gene: 22324 Mouse

Entrez Gene: 25156 Rat

Omim: 164875 Human

SwissProt: P15498 Human

SwissProt: P27870 Mouse

SwissProt: P54100 Rat

Unigene: 116237 Human

Unigene: 248172 Mouse

Unigene: 48861 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Vav1蛋白是特異于造血細(xì)胞表達(dá)的鳥苷酸轉(zhuǎn)換因子,它參與了多種免疫細(xì)胞如T細(xì)胞,B細(xì)胞,巨噬細(xì)胞,自然殺傷性細(xì)胞等的胞內(nèi)信號轉(zhuǎn)導(dǎo),發(fā)揮著重要作用. Vav1主要參與T細(xì)胞信號傳導(dǎo)途徑,傳導(dǎo)信號激活鈣流、細(xì)胞外信號調(diào)節(jié)激酶(ERK)以及轉(zhuǎn)錄因子NFκB。Vav1蛋白在T細(xì)胞生長發(fā)育、成熟T細(xì)胞激活、細(xì)胞因子合成及細(xì)胞骨架活動中發(fā)揮重要作用。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产乱女乱子视频在线播放 | 欧美一级二级三级 | 欧美日韩另类在线观看视频 | 伊人久久大香线蕉成人综合网 | 文中字幕一区二区三区视频播放 | 国产真实女人一级毛片 | 久久久久久久久免费视频 | 国产真实老熟女无套内射 | 成 人影片 免费观看 | 欧美日韩精品一区二区三区高清视频 | 一本大道AV人久久综合 | 国产大爆乳大爆乳在线播放 | 国产在线观看无码免费视频 | 国产女主播喷水视频在线观看 | 成人免费的性色视频网站 | 国产高清japanese国产 | 男人裸身露j不挡的图片 | 免费久久99精品国产自在现 | 天堂资源中文最新版在线一区 | 国产在线高清视频 | 精品国产午夜肉伦伦影院 | 麻豆文化传媒精品1区2区3区 | 日日操夜夜操视频 | 国产免费成人在线视频 | 欧美性爱视频免费观看 | 欧美人与动牲交A精品 | 中韩高清无专码区2021曰 | 欧美疯狂做受xxxxx喷水 | 动漫爆乳无遮挡免费观看 | 无码AV天堂亚洲内射夫妻 | 91热久久免费精品99 | 影音先锋女人AA鲁色资源 | 男女后进式猛烈XX00动态图片 | 性色A码一区二区三区天美传媒 | 亚洲精品天天影视综合网 | 91免费视频网站 | 国产精品一区二区四区 | 亚洲中文字幕无码中文字 | 久久夜色撩人精品国产小说 | 又大又紧又粗c死你视频 | 午夜欧美日韩国产福利91不卡一区二区三区 |