亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
欧美全透明薄纱无内衣秀,亚洲天天在线日亚洲洲精
Rabbit Anti-phospho-VAV1 (Tyr174) /BF350 Conjugated antibody (bs-5594R-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-5594R-BF350
英文名稱 Rabbit Anti-phospho-VAV1 (Tyr174) /BF350 Conjugated antibody
中文名稱 BF350標(biāo)記的磷酸化鳥苷酸轉(zhuǎn)換因子VAV1抗體
別    名 VAV1(phospho Y174); Oncogene vav; p95Vav; Protooncogene vav; Proto-oncogene vav; VAV 1; VAV 1 oncogene; VAV; Vav proto oncogene; Vav proto-oncogene; VAV_HUMAN; VAV1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  染色質(zhì)和核信號  信號轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  G蛋白偶聯(lián)受體  t-淋巴細(xì)胞  b-淋巴細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Horse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 98kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human VAV1 around the phosphorylation site of Tyr174
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012].

Function:
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

Subunit:
May interact with CCPG1. Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. Interacts with SHB and CLNK. Interacts with THEMIS2. Interacts with HCK. Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with ITK. Interacts with PTK2B/PYK2. Interacts (via SH2 domain) with SYK. Interacts with ANKRD54.

Tissue Specificity:
Widely expressed in hematopoietic cells but not in other cell types.

Post-translational modifications:
Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS). Phosphorylated by FYN.

Similarity:
Contains 1 CH (calponin-homology) domain.
Contains 1 DH (DBL-homology) domain.
Contains 1 PH domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 SH2 domain.
Contains 2 SH3 domains.

Database links:

Entrez Gene: 7409 Human

Entrez Gene: 22324 Mouse

Entrez Gene: 25156 Rat

Omim: 164875 Human

SwissProt: P15498 Human

SwissProt: P27870 Mouse

SwissProt: P54100 Rat

Unigene: 116237 Human

Unigene: 248172 Mouse

Unigene: 48861 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Vav1蛋白是特異于造血細(xì)胞表達(dá)的鳥苷酸轉(zhuǎn)換因子,它參與了多種免疫細(xì)胞如T細(xì)胞,B細(xì)胞,巨噬細(xì)胞,自然殺傷性細(xì)胞等的胞內(nèi)信號轉(zhuǎn)導(dǎo),發(fā)揮著重要作用. Vav1主要參與T細(xì)胞信號傳導(dǎo)途徑,傳導(dǎo)信號激活鈣流、細(xì)胞外信號調(diào)節(jié)激酶(ERK)以及轉(zhuǎn)錄因子NFκB。Vav1蛋白在T細(xì)胞生長發(fā)育、成熟T細(xì)胞激活、細(xì)胞因子合成及細(xì)胞骨架活動中發(fā)揮重要作用。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
久久久久久曰本av免费免费 | 伊人久久大香线蕉AV超碰 | 日本最新精品视频在线播放 | 日韩一区二区三区四区区区 | 亚洲午夜福利在线视频 | 伊人久久大香线蕉成人综合网 | A级毛片久久久久久精品 | 国产精品久久国产精品99 | 一牛影视传媒有限公司官网 | 2012中文字幕一页免费 | 婷婷五月综合缴情在线视频 | jk黑色丝袜美腿老师啪啪 | 女人被狂躁到爽动态gif图 | 一本色道久久88综合日韩精品 | 美女赤裸裸一丝不遮的图片动图 | 99精品无码一区二区毛片免费 | 免费可以看黄的视频s色 | 99久女女精品视频在线观看 | 久久久久久高清毛片一级黑人免费 | 国产内射老熟女AAAA㏄ww | 亚洲区中文字幕在线不卡电影 | 国产久爱青草视频在线观看 | 国产高清视频免费最新在线 | 国产乱来乱子视频 | 五月的丁香六月的婷婷免费无毒不卡 | 特级毛片内射WWW无码 | 国产美女精品一区二区三区 | 成人满18在线观看网站免费 | 亚洲国产精品一区二区三区在线观看 | 豪妇荡乳1一5白玉兰免费下载 | 一区二区三区国产 | 插我舔内射18免费视频 | 中文字幕无码中文字幕有码 | 久久AV喷潮久久AV高 | 一本色道久久88综合日韩精品 | 四虎一区二区成人免费影院网址 | 色国产在线视频一区 | 丰满护士巨好爽好大乳小说 | 粗大猛烈进出高潮视频大全 | 91九色精品熟女内射 | av高清无码网址大全 |