亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
一级毛片在线免费播放,大学生一级毛片全黄真人无码,亚洲成人电影在线观看精品国产
Rabbit Anti-phospho-RAD51(Thr309)/AP Conjugated antibody (bs-5677R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-5677R-AP
英文名稱 Rabbit Anti-phospho-RAD51(Thr309)/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的磷酸化Rad51抗體
別    名 RAD51(phospho T309); BRCA1/BRCA2 containing complex, subunit 5; BRCC 5; BRCC5; DNA repair protein RAD51 homolog 1; DNA repair protein rhp51; E coli RecA homolog; HGNC:9817; Homolog of E coli RecA; homolog of S cerevisiae RAD51; HRAD51; HsRad51; HsT16930; Rad 51; RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae); RAD51 homolog; RAD51 homolog S. cerevisiae; RAD51 S cerevisiae homolog; RAD51A; RECA; RecA homolog E. coli; RecA like protein; RecA, E. coli, homolog of; recombination protein A.   
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human RAD51 around the phosphorylation site of Thr309 [GE(p-T)RI]
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript variants utilizing alternative polyA signals exist.

Function:
Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.

Subcellular Location:
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion matrix. Note=Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage. DNA damage induces an increase in nuclear levels.

Tissue Specificity:
Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast.

Post-translational modifications:
Phosphorylated. Phosphorylation of Thr-309 by CHEK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination. Phosphorylation by ABL1 inhibits function.

DISEASE:
Defects in RAD51 are a cause of susceptibility to breast cancer (BC) [MIM:114480]. A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.

Similarity:
Belongs to the RecA family. RAD51 subfamily.
Contains 1 HhH domain.

Database links:

Entrez Gene: 5888 Human

Entrez Gene: 19361 Mouse

Entrez Gene: 499870 Rat

Omim: 179617 Human

SwissProt: Q06609 Human

SwissProt: Q08297 Mouse

Unigene: 631709 Human

Unigene: 330492 Mouse

Unigene: 20474 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Rad51蛋白對(duì)細(xì)胞調(diào)節(jié)有重要作用:作為輔助因子參與DNA修復(fù)同源重組,維持正常細(xì)胞周期;Rad51蛋白在很多組織中都有不同的存在。在乳腺癌和消化系統(tǒng)等惡性腫瘤組織中表達(dá)較高,究其原因有報(bào)道稱:這是DNA被損傷后細(xì)胞的一種反應(yīng),而這種反應(yīng)不足以阻止癌變的發(fā)生。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
国内久经典AAAAA片 | 全部在线播放免费毛片 | 亚洲成人电影在线观看精品国产 | 999国内精品永久免费视频 | 91久久精品国产免费一区金莲 | 午夜福利免费一区二区小说 | 亚洲调教自慰喷水AV无码 | 91欧洲在线视精品在亚洲 | 黄色一级片免费网站 | 又粗又大又黄的少妇毛片 | 特级毛片在线大全免费播放 | 樱花草中文在线观看高清视频 | 韩国三级理论在线电影 | 裸露双乳挤奶无遮掩裸体私房视频 | 国产99视频精品免费视亚洲一级Av无码毛片久久精品 | a级毛片免费全部播放无码 日韩久久久久精品一区二区三区 | 亚洲成AV人片一区二区三区 | 日韩电影免费在线观看网站 | 亚洲欧美强伦一区二区另类 | 国产黄A三级三级三级看三级 | 久久久久亚洲精品天堂久久久久久 | 日韩综合在线观看 | 午夜.DJ高清在线观看免费7 | 欧美人与性囗牲恔配 | 在线A亚洲老鸭窝天堂AV高清 | 国产精品亚洲专区在线播放 | 亚洲欧美综合国产精品一区看三级 | 国产伦精品免编号公布 | 又小又紧女MAGNET | 久久久高清国产999尤物 | 最近最新的中文字幕国语在线 | 国产成人精品无码免费视频 | 最近中文字幕mv免费视频 | mdapptv麻豆下载 | 国产精品内射婷婷一级二 | 一区二区三区囯产精品乱码不卡 | 成人片黄网站色大片免费 | 日本那些又骚又爽的视频 | 日本在线精品视频观看 | 三上悠亚激情AV一区二区三区 | 亚洲最大的熟女水蜜桃AV网站 |