亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
小货SAO边洗澡边CAO你动漫,日韩视频在线观看,国产国拍亚洲精品永久软件
Rabbit Anti-phospho-p107(Ser975)/APC Conjugated antibody (bs-5696R-APC)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-5696R-APC
英文名稱 Rabbit Anti-phospho-p107(Ser975)/APC Conjugated antibody
中文名稱 APC標(biāo)記的磷酸化視網(wǎng)膜母細(xì)胞瘤樣蛋白p107抗體
別    名 RBL1(phospho S975); Cellular protein 107; CP107; PRB1; RBL1; Retinoblastoma like protein 1; RBL1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞周期蛋白  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 121kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human RBL1 around the phosphorylation site of Ser975
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The pocket protein family consists of three structurally and functionally related proteins, Rb (retinoblastoma), p107, and p130. This family of tumor suppressors function to regulate important cellular transcription factors, such as the E2F family. The E2F proteins regulate the expression of genes whose products are important for cell cycle progression. The inactivation Rb is catalyzed by CDK phosphorylation thereby releasing E2F during the G1-S phase cellular progression. Unchecked inactivation of Rb in G1 phase has been indicated as a universal mechanism underlying cellular transformation . While Rb has been the most studied among the pocket proteins, p107 and p130 have also been shown to be key regulators of E2F. Several studies have also provided evidence that p107/p130 provide different functions in E2F regulation than does Rb. Rb, p107, and p130 each contain a conserved 'A/B pocket', which is the target of several viral oncoproteins, namely SV40 large T-antigen and adenovirus E1A. There are two isoforms.

Function:
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.

Subunit:
Interacts with SUV420H1, SUV420H2 and USP4 (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with AATF. Interacts with KDM5A. Interacts with SV40 and JC virus large T antigens.

Subcellular Location:
Nucleus.

Post-translational modifications:
Exists in both phosphorylated and unphosphorylated forms, and T, but not E1A, binds only to the unphosphorylated form. Cell-cycle arrest properties are inactivated by phosphorylation on Thr-332, Ser-640, Ser-964 and Ser-975 by CDK4.

Similarity:
Belongs to the retinoblastoma protein (RB) family.

Database links:

Entrez Gene: 5933 Human

Entrez Gene: 19650 Mouse

Entrez Gene: 680111 Rat

Omim: 116957 Human

SwissProt: P28749 Human

SwissProt: Q64701 Mouse

Unigene: 207745 Human

Unigene: 244671 Mouse

Unigene: 148725 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
久久er热在这里只有精品66 到这里 | 无码爽到爆高潮抽搐喷水在线观看 | 正在播放国产精品 | 欧洲妓女在线视频免费看 | 欧美性狂猛bbbbbbxxxx | 免费va国产高清大片在线 | 超级乱淫片午夜电影网99 | 永久黄网站色视频免费观看 | 亚洲乱码国产乱码精品精乡村 | 国产精品亚洲精品专区 | 久久人人爽人人爽人人片AV不 | 娇妻被领导玩整夜不停 | 亚洲熟妇av一区二区三区色堂 | 亚洲成AV人片一区二区不卡 | A级成人毛片免费视频 | 国产69精品久久久久999小说 | 欧美激情一区二区三区蜜桃视频 | 欧洲性开放大片免费观看视频 | 精品国产一区二区三区 | 成人无遮挡免费网站视频在线观看 | 久久精品动漫99国产精品动漫 | 国产精品久久久久久久久久免费 | 男人天堂网在线视频观看 | 绿意盎然侄子小钢炮的成长经历 | 久久99AV无色码人妻蜜 | 特级做a爰片毛片免费69 | 最新高清无码专区 | 在线无码一区二区三区不卡 | 好爽又高潮了毛片免费下载 | 特级精品毛片免费观看 | 午夜福利一区二区三区高清视频 | 伊人色综合久久天天人守人婷 | 亚洲AV无码专区在线观看播放 | 久久精品中文字幕无码有码 | 无码不卡免费v片在线观看 国产未发育呦交视频 | 亚洲日韩在线观看 | 嫩交18xxxx | 公的大龟慢慢挺进我的体内视频 | 中文字幕高清免费日韩视频在线 | 琪琪精品视频在线观看 | 久久婷婷97人妻无码狠狠综合久久久久综合 |