亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国模大胆一区二区三区,国产精品久久久久久久久免费蜜桃,一级毛片在线播放观看
Rabbit Anti-CHFR/PE-Cy3 Conjugated antibody (bs-4272R-PE-Cy3)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-4272R-PE-Cy3
英文名稱 Rabbit Anti-CHFR/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標(biāo)記的泛素連接酶蛋白CHFR抗體
別    名 Checkpoint with forkhead and ring finger domains; Checkpoint with forkhead and RING finger domains protein; E3 ubiquitin protein ligase CHFR; EC 6.3.2.; RING finger protein 196; RNF 116; RNF 196; RNF116; RNF196; Ubiquitin ligase protein; CHFR_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號(hào)  細(xì)胞周期蛋白  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 73 kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CHFR
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
A number of human cancers are sensitive to mitotic stress, implying checkpoint defects. Many proteins that contain forkhead-associated (FHA) domains are cell cycle checkpoints and CHFR is one such protein. It has a FHA and ring finger domain within its N terminus. Within its C terminus, CHFR contains a cysteine-rich region that did not display significant similarity to any protein in the GenBank database, but is highly conserved between humans and mice. It has been concluded that CHFR defines a checkpoint that delays entry into metaphase in response to mitotic stress. It has been found CpG methylation-dependent silencing of CHFR expression occurs in 45% of cancer cell lines, 40% of primary colorectal cancers, 53% of colorectal adenomas, and 30% of primary head and neck cancers.

Function:
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.

Subunit:
Interacts with HDAC1 and HDAC2. Interacts with PML (with sumoylated form of PML).

Subcellular Location:
Nucleus, PML body.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Poly-ADP-ribosylated. In addition to binding non covalently poly(ADP-ribose) via its PBZ-type zinc finger, the protein is also covalently poly-ADP-ribosylated by PARP1.
Autoubiquitinated; may regulate its cellular level.
Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). Phosphorylated by PKB. Phosphorylation may affect its E3 ligase activity.

Similarity:
Belongs to the CHFR family.
Contains 1 FHA domain.
Contains 1 PBZ-type zinc finger.
Contains 1 RING-type zinc finger.

Database links:

Entrez Gene: 55743 Human

Entrez Gene: 231600 Mouse

Omim: 605209 Human

SwissProt: Q96EP1 Human

SwissProt: Q810L3 Mouse

Unigene: 720197 Human

Unigene: 30264 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
亚洲第一区第二区 | 国产普通话对白呻吟在线 | 日韩电影免费在线观看网站 | 国产AAA片精品网站 打扑克污黄对网站在线看 男女激情射精国产精品久久 | √天堂资源地址在线官网 | 荡娃艳妇有声小说 | 日韩一区二无码专区播放 | 一女侍七夫巨H双修 | 无码AV动漫精品一区二区免费 | 91福利国产在线观看网站 | 国产精品动漫网站入口大全 | 亚州日本乱码一区二区三区 | 性啪啪chinese东北女人 | 久久国产91成人免费网站 | 少妇野外一级内射婬片免费放 | 国产欧美日韩一区二区搜索 | 一本大道香蕉综合视频在线观看 | 中文字幕乱偷无码AV蜜桃 | 精品无人乱码一区二区三区 | 中文字幕一区二区视频 | 一本大道香蕉久在线播放29 | 么公又大又硬又粗又长 | AAA日本高清在线播放免费观看 | 97在线精品视频免费 | 青青久在线视频免费观看 | 久久久橹橹橹久久久久高清 | 美女裸免费观看网站 | 我国产码在线观看AV哈哈哈网站 | 中国内射XXXX6981少妇 | 国产偷国产偷亚州清高APP | 久久爱影院久久99久国产 | 久久久久精品国产亚洲HAV无码 | 影音先锋亚洲AV少妇熟女 | 国产精品久久久久久精品爆乳 | 18成人片黄网站WWW | 无码一级a一片免费看 | 欧美性videos高清精品 | 96精产国品一二三产品区别 | 久久久久成亚洲国产av综合精品 | 久久久国产精品免费看 | 亚洲精品沙发午睡系列 |