亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質(zhì)量反饋  關于我們  聯(lián)系我們
亚洲精品成A人在线观看,亚洲一区二区视频在线观看 ,亚1州区2区3区4区产品图片
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-CHFR/PE-Cy5 Conjugated antibody (bs-4272R-PE-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-4272R-PE-Cy5
英文名稱 Rabbit Anti-CHFR/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標記的泛素連接酶蛋白CHFR抗體
別    名 Checkpoint with forkhead and ring finger domains; Checkpoint with forkhead and RING finger domains protein; E3 ubiquitin protein ligase CHFR; EC 6.3.2.; RING finger protein 196; RNF 116; RNF 196; RNF116; RNF196; Ubiquitin ligase protein; CHFR_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  染色質(zhì)和核信號  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Rabbit, )
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 73 kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CHFR
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
A number of human cancers are sensitive to mitotic stress, implying checkpoint defects. Many proteins that contain forkhead-associated (FHA) domains are cell cycle checkpoints and CHFR is one such protein. It has a FHA and ring finger domain within its N terminus. Within its C terminus, CHFR contains a cysteine-rich region that did not display significant similarity to any protein in the GenBank database, but is highly conserved between humans and mice. It has been concluded that CHFR defines a checkpoint that delays entry into metaphase in response to mitotic stress. It has been found CpG methylation-dependent silencing of CHFR expression occurs in 45% of cancer cell lines, 40% of primary colorectal cancers, 53% of colorectal adenomas, and 30% of primary head and neck cancers.

Function:
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.

Subunit:
Interacts with HDAC1 and HDAC2. Interacts with PML (with sumoylated form of PML).

Subcellular Location:
Nucleus, PML body.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Poly-ADP-ribosylated. In addition to binding non covalently poly(ADP-ribose) via its PBZ-type zinc finger, the protein is also covalently poly-ADP-ribosylated by PARP1.
Autoubiquitinated; may regulate its cellular level.
Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). Phosphorylated by PKB. Phosphorylation may affect its E3 ligase activity.

Similarity:
Belongs to the CHFR family.
Contains 1 FHA domain.
Contains 1 PBZ-type zinc finger.
Contains 1 RING-type zinc finger.

Database links:

Entrez Gene: 55743 Human

Entrez Gene: 231600 Mouse

Omim: 605209 Human

SwissProt: Q96EP1 Human

SwissProt: Q810L3 Mouse

Unigene: 720197 Human

Unigene: 30264 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产精品日产欧美久久久 | 国产精品免费视频能看 | 国产麻豆成人传媒免费观看 | 日韩欧美视频一区 | 欧美精品久久久久久久小说 | 后入白嫩网红内射99XYZ | 一二三四中文字幕 | 久久久高清免费视频 | 国产精品一国产AV麻豆 | 91热久久免费精品99 | 国产午夜激无码Av片在线观看 | 午夜欧美日韩精品久久久久久 | 国产白嫩漂亮美女在线观看 | 国产一级特黄A片高潮片 | 欧美成人久久一级c片免费 免费视频国产在线观看 | 动漫男女肉肉全彩无遮挡 | 久久久精品国产亚州AV水蜜桃 | 国产精品三P一区二区视频 最近高清中文字幕免费MV | 国内精品久久久久久网站 | 亚洲AV无码久久久久久精品酒店 | 内射人妻无套中出无码 | 久久天天躁狠狠躁夜夜97 | 国产欧美日韩灭亚洲精品 | 99精品无码一区二区毛片免费 | 亚洲午夜精品无码专区在线播放 | 宅男午夜大片又黄又爽大片 | 在线无码一区二区三区不卡 | 琪琪精品视频在线观看 | 豆奶视频在线观看免费高清版 | 国产成人在线播放 | 人妻中文字幕乱人伦在线 | 国产综合视频在线观看一区 | 美女狂揉尿口揉到失禁 | 日韩无码高清福利在线看 | se01在线看片 | 国产高颜值大学生情侣酒店 | 亚洲H在线播放在线观看H | 无码高潮喷水在线播放观看 | 日本一卡二卡不卡视频查询 | 欧美特级午夜一区二区三区 | 少妇高潮好爽在线播放 |