亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
欧美一级久久久久久久久大,成 人片 黄 色 大 片,色欲精品人妻AV一区二区三区
Rabbit Anti-CHFR/APC Conjugated antibody (bs-4272R-APC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-4272R-APC
英文名稱 Rabbit Anti-CHFR/APC Conjugated antibody
中文名稱 APC標(biāo)記的泛素連接酶蛋白CHFR抗體
別    名 Checkpoint with forkhead and ring finger domains; Checkpoint with forkhead and RING finger domains protein; E3 ubiquitin protein ligase CHFR; EC 6.3.2.; RING finger protein 196; RNF 116; RNF 196; RNF116; RNF196; Ubiquitin ligase protein; CHFR_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號(hào)  細(xì)胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 73 kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CHFR
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
A number of human cancers are sensitive to mitotic stress, implying checkpoint defects. Many proteins that contain forkhead-associated (FHA) domains are cell cycle checkpoints and CHFR is one such protein. It has a FHA and ring finger domain within its N terminus. Within its C terminus, CHFR contains a cysteine-rich region that did not display significant similarity to any protein in the GenBank database, but is highly conserved between humans and mice. It has been concluded that CHFR defines a checkpoint that delays entry into metaphase in response to mitotic stress. It has been found CpG methylation-dependent silencing of CHFR expression occurs in 45% of cancer cell lines, 40% of primary colorectal cancers, 53% of colorectal adenomas, and 30% of primary head and neck cancers.

Function:
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.

Subunit:
Interacts with HDAC1 and HDAC2. Interacts with PML (with sumoylated form of PML).

Subcellular Location:
Nucleus, PML body.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Poly-ADP-ribosylated. In addition to binding non covalently poly(ADP-ribose) via its PBZ-type zinc finger, the protein is also covalently poly-ADP-ribosylated by PARP1.
Autoubiquitinated; may regulate its cellular level.
Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). Phosphorylated by PKB. Phosphorylation may affect its E3 ligase activity.

Similarity:
Belongs to the CHFR family.
Contains 1 FHA domain.
Contains 1 PBZ-type zinc finger.
Contains 1 RING-type zinc finger.

Database links:

Entrez Gene: 55743 Human

Entrez Gene: 231600 Mouse

Omim: 605209 Human

SwissProt: Q96EP1 Human

SwissProt: Q810L3 Mouse

Unigene: 720197 Human

Unigene: 30264 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
中文字幕在线免费观看 | 国产一级欧美精品大片免费看 | 真人一级一级毛片免费观看 | 精品一区二区久久久久久久网精 | 精品亚洲一区二区三区在线观看 | 国产成人综合亚洲欧美在线观看 | 日韩一区二区超清视频 | 印度一级特黄AAAAAA片在线看 | A级黄韩国在线观看免费 | 精品卡一卡二卡3卡高清乱码 | q2002午夜我的老师 | 国产精品久久一区二区三蜜桃 | 国产中文字幕久久精品网址 | 强插女教师AV在线 | 欧洲VIDEOS重口变态深 | 天堂MV在线MV免费MV香蕉 | 天天躁日日躁狠狠躁AV麻豆 | 91久久综合精品国产丝袜长腿 | 免费毛片网站在线观看 | 亚洲AⅤ永久无码精品毛片费观看 | 久久97久久精品免费观看黑人 | 国产成人精品免高潮在线观看 | 麻豆一区产品精品蜜桃的广告语 | √8天堂资源地址中文在线 欧美精品成人一区二区在线观看 | 91精品国产色综合久久不卡美美 | 丰满妇女BBWBBWBBWBBW | 老司机无码精品A | 亚洲精品成a人在线观看 | 国产又猛又黄又爽 | 92婷婷伊人久久精品一区 | 欧美人与黑人牲交全过程视 | 欧美日韩人妻精品一区在线 | 日韩美女乱淫试看屁视频网站 | 蜜桃臀无码内射一区二区三区 | 欧美一区二区三区不卡免费 | 日韩一级特黄毛片在线看 | 一级毛片免费视频网站 | 99re久久在热线播放最新地址 | 国产日产欧产精品精品 | 午夜.DJ高清在线观看免费7 | 国产午夜精品理论片小yo奈 |