亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
善良娇妻在老汉跨下呻吟,女人扒开腿让男人狂桶30分钟,人人揉人人捏人人爽五月天
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-CHFR/BF488 Conjugated antibody (bs-4272R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-4272R-BF488
英文名稱 Rabbit Anti-CHFR/BF488 Conjugated antibody
中文名稱 BF488標記的泛素連接酶蛋白CHFR抗體
別    名 Checkpoint with forkhead and ring finger domains; Checkpoint with forkhead and RING finger domains protein; E3 ubiquitin protein ligase CHFR; EC 6.3.2.; RING finger protein 196; RNF 116; RNF 196; RNF116; RNF196; Ubiquitin ligase protein; CHFR_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  染色質和核信號  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 73 kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CHFR
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
A number of human cancers are sensitive to mitotic stress, implying checkpoint defects. Many proteins that contain forkhead-associated (FHA) domains are cell cycle checkpoints and CHFR is one such protein. It has a FHA and ring finger domain within its N terminus. Within its C terminus, CHFR contains a cysteine-rich region that did not display significant similarity to any protein in the GenBank database, but is highly conserved between humans and mice. It has been concluded that CHFR defines a checkpoint that delays entry into metaphase in response to mitotic stress. It has been found CpG methylation-dependent silencing of CHFR expression occurs in 45% of cancer cell lines, 40% of primary colorectal cancers, 53% of colorectal adenomas, and 30% of primary head and neck cancers.

Function:
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.

Subunit:
Interacts with HDAC1 and HDAC2. Interacts with PML (with sumoylated form of PML).

Subcellular Location:
Nucleus, PML body.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Poly-ADP-ribosylated. In addition to binding non covalently poly(ADP-ribose) via its PBZ-type zinc finger, the protein is also covalently poly-ADP-ribosylated by PARP1.
Autoubiquitinated; may regulate its cellular level.
Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). Phosphorylated by PKB. Phosphorylation may affect its E3 ligase activity.

Similarity:
Belongs to the CHFR family.
Contains 1 FHA domain.
Contains 1 PBZ-type zinc finger.
Contains 1 RING-type zinc finger.

Database links:

Entrez Gene: 55743 Human

Entrez Gene: 231600 Mouse

Omim: 605209 Human

SwissProt: Q96EP1 Human

SwissProt: Q810L3 Mouse

Unigene: 720197 Human

Unigene: 30264 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
丰满少妇被猛男猛烈进入久久 | 日韩AV片无码一区二区三区不卡 | 最近免费中文字幕MV免费高清 | 亚洲人AV永久一区二区三区久久 | 最近高清中文字幕无吗免费看 | 真实国产精品视频国产网 | 全免费A级毛片免费看无码播放 | 无码国产精品一区二区免费式芒果 | 免费无码无遮挡在线V视频 全黄裸片一29分钟免费真人版 | 日本产品和韩国产品哪个好99 | 日本强好片久久久久久AAA | 老司机久久精品最新免费 | 久久久久成亚洲国产av综合精品 | 中文字幕一区二区精品区 | 欧美日韩一区在线观看 | 乖乖张开腿让我亲欲欲成欢 | 国产在线精品福利大全 | 丰满爆乳肉感一区二区三区 | 亚洲一区二区三区免费看 | 久久久久国产精品夜夜夜夜夜 | 国产成人无码AⅤ片在线 | 国产免费AV片在线播放唯爱网 | 日韩人妻高清精品专区 | 久久国产精品-久久精品 | 亚洲综合另类欧美久久久久精品 | 性生生活色欲片性按摩 | 自拍偷区亚洲综合第一页欧18 | 亚洲一区二区三区免费看 | 国产欧美日韩精品一区二区三区蜜桃不卡 | 欧美激情一区二区三区视频 | 免费一级毛片私人影院a行 99精产国品一二三产 | 午夜尤物禁止18点击进入 | 在线视频中文2021 | 亚洲成av人影院 | 欧美黄色一级视频 | 日产粗又猛又爽又黄的视频 | 久久婷婷五月国产色综合 | 重口SM一区二区三区视频 | 中文字日产幕码三区的做法大全 | 最新中文字幕A片专区 | 中文字幕久久精品无码综合网 |