亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
91久久精品美女高潮喷水白浆,青青草国产免费一区二区
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-KMT1A/Cy3 Conjugated antibody (bs-5708R-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-5708R-Cy3
英文名稱 Rabbit Anti-KMT1A/Cy3 Conjugated antibody
中文名稱 Cy3標記的組蛋白H3 K9甲基轉移酶抗體
別    名 H3 K9 HMTase; H3 K9 HMTase1; H3-K9-HMTase 1; Histone H3 K9 methylation; Histone H3 Lys 9 methylation; Histone H3-K9 methyltransferase 1; Histone H3-K9 methyltransferase1; Histone lysine N methyltransferase H3 lysine 9 specific 1; Histone lysine N methyltransferase, H3 lysine 9 specific 1; Histone-lysine N-methyltransferase SUV39H1; KMT1 A; Lysine N methyltransferase 1A; Lysine N-methyltransferase 1A; MG44; mIS6; Position-effect variegation 3-9 homolog; Su(var)3 9 homolog 1; Su(var)3-9 homolog 1; Suppressor of variegation 3 9 homolog 1 (Drosophila); Suppressor of variegation 3-9 homolog 1; SUV39 H1; SUV39H; SUV39H1; SUV91_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  染色質和核信號  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, )
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Histone H3 Lys 9 methylation/SUV39H1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus.

Function:
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus.

Subunit:
nteracts with H3 and H4 histones. Interacts with GFI1B, DNMT3B, CBX1, CBX4, KIAA1967/DBC1, MBD1, RUNX1, RUNX3, MYOD1, SMAD5 and RB1. Interacts with SBF1 through the SET domain. Interacts with HDAC1 and HDAC2 through the N-terminus and associates with the core histone deacetylase complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. In case of infection, interacts with HTLV-1 Tax protein, leading to abrogate Tax transactivation of HTLV-1 LTR. Interacts (via SET domain) with MECOM; enhances MECOM transcriptional repression activity (By similarity).

Subcellular Location:
Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.

Post-translational modifications:
Phosphorylated on serine residues, and to a lesser degree, on threonine residues. The phosphorylated form is stabilized by SBF1 and is less active in its transcriptional repressor function.
Acetylated at Lys-266, leading to inhibition of enzyme activity. SIRT1-mediated deacetylation relieves this inhibition.

Similarity:
Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily.
Contains 1 chromo domain.
Contains 1 post-SET domain.
Contains 1 pre-SET domain.
Contains 1 SET domain.

Database links:

Entrez Gene: 6839 Human

Entrez Gene: 20937 Mouse

Entrez Gene: 302553 Rat

Omim: 300254 Human

SwissProt: O43463 Human

SwissProt: O54864 Mouse

Unigene: 522639 Human

Unigene: 479743 Mouse

Unigene: 9244 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
少妇被躁爽到高潮无码麻豆AV | 亚洲AV无码一区二区三区在线高 | 日韩精品极品视频在线观看免费 | 动漫精品中文无码卡通动漫 | 日韩一区二区免费视频 | 国产一级无码免费不卡| 国产精品视频26uuu | 被三个男人绑着躁我好爽 | 在线观看欧美人与动物性交 | 国产欧美日韩高清在线不卡 | 国产一区二区免费在线观看 | 91性高湖久久久久久久久 | 国产麻豆剧传媒精品国产AV | 五月天婷亚洲天久久综合网 | 欧美乱妇日本无乱码特黄大片 | a无码亚洲男人的天堂 | 精产国蘑菇品一二三产品区 | 国产乱女乱子视频在线播放 | 国产一区二区三区内射高清 | 国产乱熟肥女视频网站 | 久久久无码人妻精品无码 | 精品久久久亚洲精品中文字幕 | 国产精品原创巨作AV | 换脸国产AV一区二区三区 | 亚洲中文字幕在线乱妇 | 神马手机影院未来影院 | 免费 无码 国产在线观 | 国产免费久久精品99re丫y | 国产真人无遮挡作爱免费视频 | 亚洲AV无码成人精品区东京热 | 欧美性生活视频免费播放网址大全观看 | 国产成人午夜精品免费视频 | 久久精品综合网人人妻 | 欧美人妻精品一区二区三区 | 精品一区二区三区无码av孕妇 | A级毛片久久久久久精品 | 好涩啊揉爆骚奶的视频 | 欧美日韩另类在线观看视频 | 国产又爽又黄又不遮挡视频 | 久久国产精品偷任你爽任你A | 欧美曰韩日B大片在线看 |