亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
熟妇丰满大屁股在线播放BBW,高潮无码精品色欲av午夜福利
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Axin 2/Gold Conjugated antibody (bs-5717R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-5717R-Gold
英文名稱 Rabbit Anti-Axin 2/Gold Conjugated antibody
中文名稱 膠體金標記的軸抑制蛋白2抗體
別    名 Axil; Axin like protein; Axin-2; Axin-like protein; Axin2; Axis inhibition protein 2; AXIN2_HUMAN; Conductin.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 腫瘤  細胞生物  免疫學  神經生物學  信號轉導  干細胞  細胞周期蛋白  轉錄調節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Dog, Horse, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 93kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Axin 2 corresponding to amino acids 756-795
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Involvement in disease:Defects in AXIN2 are involved in colorectal cancer (CRC). They appear to be specifically associated with defective mismatch repair.
Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (ODCRCS). Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.

Function:
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity).

Subunit:
Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin (By similarity). Interacts with SMAD7 and RNF111. Interacts with ANKRD6.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in brain and lymphoblast.

Post-translational modifications:
Probably phosphorylated by GSK3B and dephosphorylated by PP2A (By similarity).
ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway.
Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.

DISEASE:
Defects in AXIN2 are involved in colorectal cancer (CRC) [MIM:114500]. They appear to be specifically associated with defective mismatch repair.
Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (ODCRCS) [MIM:608615]. Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.

Similarity:
Contains 1 DIX domain.
Contains 1 RGS domain.

Database links:

Entrez Gene: 8313 Human

Entrez Gene: 12006 Mouse

Entrez Gene: 29134 Rat

Omim: 604025 Human

SwissProt: Q9Y2T1 Human

SwissProt: O88566 Mouse

SwissProt: O70240 Rat

Unigene: 156527 Human

Unigene: 71710 Mouse

Unigene: 162212 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
日本xXXx色视频在线播放 | 中国bbwbbw| 无码一区二区三区亚洲人妻 | 少妇人妻偷人精品视蜜桃 | 欧美日韩精品一区二区三区高清视频 | 久久亚洲美日韩精品无码一区二区 | 男女无遮挡XX00动态图120秒 | 丰满肥妇BBWBBWBBWBBW | 久久久精品中文字幕麻豆发布 | 国产精品亚洲av综合成久久久久久三级 | 99人中文字幕亚洲区三 | 99精品无人区乱码1区2区3区 | 亚洲日韩在线中文字幕一区 | 国色天香视频免费高清社区 | 国产情侣真实露脸在线 | 免费国产黄网在线观看 | 久久婷婷品香蕉频线观2021 | 适合晚上看的东西免费软件 | 野花高清在线观看免费 | 精品国产午夜肉伦伦影院 | 久久99久国产精品黄毛片 | 欧美韩国人成网站中文字幕 | 国产精品免费视频一区二区三区 | 少妇又紧又色又爽又刺激视频 | 国产无码视频在线观看 | 最新国学生自产拍短视频 | 国产精品亚洲lv粉色 | 午夜三级a三级三点窝558888 | XX性欧美肥妇精品久久久久久 | www.xxxx日本 | 中国特级黄一级**毛片 | 四川小少妇BBAABBAA | 国产精品中文原创AV巨作首播 | 污污内射一区二区三区 | 50岁老熟女露脸25分钟91 | 一本大道香蕉久在线播放看 | 熟妇丰满大屁股在线播放BBW | 美女性爽视频国产免费 | 99re免费观看国产在线观看 | 欧美mv日韩mv国产mv网站 | 最近最新免费手机中文 |