亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
99热门精品一区二区,又黄又猛又爽大片免费
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Axin 2/Cy5.5 Conjugated antibody (bs-5717R-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-5717R-Cy5.5
英文名稱 Rabbit Anti-Axin 2/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標記的軸抑制蛋白2抗體
別    名 Axil; Axin like protein; Axin-2; Axin-like protein; Axin2; Axis inhibition protein 2; AXIN2_HUMAN; Conductin.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  神經生物學  信號轉導  干細胞  細胞周期蛋白  轉錄調節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Dog, Horse, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 93kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Axin 2 corresponding to amino acids 756-795
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Involvement in disease:Defects in AXIN2 are involved in colorectal cancer (CRC). They appear to be specifically associated with defective mismatch repair.
Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (ODCRCS). Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.

Function:
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity).

Subunit:
Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin (By similarity). Interacts with SMAD7 and RNF111. Interacts with ANKRD6.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in brain and lymphoblast.

Post-translational modifications:
Probably phosphorylated by GSK3B and dephosphorylated by PP2A (By similarity).
ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway.
Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.

DISEASE:
Defects in AXIN2 are involved in colorectal cancer (CRC) [MIM:114500]. They appear to be specifically associated with defective mismatch repair.
Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (ODCRCS) [MIM:608615]. Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.

Similarity:
Contains 1 DIX domain.
Contains 1 RGS domain.

Database links:

Entrez Gene: 8313 Human

Entrez Gene: 12006 Mouse

Entrez Gene: 29134 Rat

Omim: 604025 Human

SwissProt: Q9Y2T1 Human

SwissProt: O88566 Mouse

SwissProt: O70240 Rat

Unigene: 156527 Human

Unigene: 71710 Mouse

Unigene: 162212 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
精品国产髙清在线看国产毛片 | 欧洲美女高清一级毛片 | 美女脱了奶罩看到大乳 | 日韩一级视频在线观看播放 | 97久精品国产片一区二区三区 | 久久久久久久无码中文字幕爆 | 亚洲精品天天影视综合网 | 欧美日韩一区精品视频一区二区 | 色欲久久精品亚洲AV无码一区 | 国产一区二区视频在线观看 | 国产美女一级做视频爱 | 日韩欧美高清黄大片色成人精品香蕉在线看 | 91精品国产高清一区二区三密臀 | 国产伦精品一区二区高清版 | 欧美三级片a片在线观看 | 日欧一片内射va在线影院 | 成熟丰满女人免费视频 | 久久久久久精品免费免费WE | 麻豆精产国品免费免费观看高清 | 在线视频中文2021 | 日韩在线永久免费播放 | 国产在线观看清码视频 | 免费无码又爽视频在线观看 | 国产欧美一区二区三区久久 | 捣烂宫口np失禁哭张开了h | 丁香花在线影院观看在线播放 | WWW夜片内射视频日韩精品成人 | 亚洲国产精品一区二区动图 | 亚洲欧美一区二区三区孕妇写真 | 黄色网址视频在线播放 | 伊人久久大香线蕉成人综合网 | 亚洲日韩精品A∨在线观看 欧美a∨亚洲欧美亚洲 | 国产精品一区二区AV日韩在线 | 国产精品免费视频一区二区三区 | 双飞风韵犹存两个熟妇 | 中文字幕无限乱码不卡2021 | 国产午夜精品一区二区三区软件 | 91精品国产免费久久久久久 | 丰满妇女BBWBBWBBWBBW | 一级a性色生活片久久毛片 日韩欧美一中文字慕2O22 | 综合人妻久久一区二区精品 |