亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
AV无码免费一区二区三区不卡 ,aaaaaa级特色特黄的毛片
Rabbit Anti-Axin 2/Cy7 Conjugated antibody (bs-5717R-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-5717R-Cy7
英文名稱 Rabbit Anti-Axin 2/Cy7 Conjugated antibody
中文名稱 Cy7標(biāo)記的軸抑制蛋白2抗體
別    名 Axil; Axin like protein; Axin-2; Axin-like protein; Axin2; Axis inhibition protein 2; AXIN2_HUMAN; Conductin.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞周期蛋白  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Dog, Horse, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 93kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Axin 2 corresponding to amino acids 756-795
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Involvement in disease:Defects in AXIN2 are involved in colorectal cancer (CRC). They appear to be specifically associated with defective mismatch repair.
Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (ODCRCS). Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.

Function:
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity).

Subunit:
Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin (By similarity). Interacts with SMAD7 and RNF111. Interacts with ANKRD6.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in brain and lymphoblast.

Post-translational modifications:
Probably phosphorylated by GSK3B and dephosphorylated by PP2A (By similarity).
ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway.
Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.

DISEASE:
Defects in AXIN2 are involved in colorectal cancer (CRC) [MIM:114500]. They appear to be specifically associated with defective mismatch repair.
Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (ODCRCS) [MIM:608615]. Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.

Similarity:
Contains 1 DIX domain.
Contains 1 RGS domain.

Database links:

Entrez Gene: 8313 Human

Entrez Gene: 12006 Mouse

Entrez Gene: 29134 Rat

Omim: 604025 Human

SwissProt: Q9Y2T1 Human

SwissProt: O88566 Mouse

SwissProt: O70240 Rat

Unigene: 156527 Human

Unigene: 71710 Mouse

Unigene: 162212 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
久久夜色国产亚洲色欲AV | 91网站永久免费看nba视频 | 精品一区二区三区在线成人 | 怡红院日本一道日本久久 | 亚洲人成人网毛片在线播放 | 国产一级一片免费播放i | aaaaaaa一级毛片 | 九九综合VA免费看 | 久久久久久国产a免费观看黄色大片 | 国产二级一片内射视频插放 | 911国产自产精品a | 婷婷六月激情综合一区 | 高清少妇熟女一区二区 | zps无套内射视频免费播放 | 国产成人久久精品二三区麻豆 | 日本一级婬片A片免费播放曰i | 国产精品三P一区二区视频 最近高清中文字幕免费MV | 亚洲国产精品特色大片观看完整版 | 91普通话国产对白在线 | 久久久久久久Aⅴ无码免费网站 | 中文字幕一区二区人妻性色 | 国产成a人亚洲精v品久久网 | 麻豆精品传媒一二三区 | 国产午夜无码精品免费看浪潮 | 狂躁美女大BBBBBB视频1 | 亚洲国产精品一区二区动图 | 456亚洲人成影院在线观 | 国产放荡AV剧情演绎麻豆 | 久久精品国产免费观看频道 | 精品丝袜久久久久人妻 | 国产亚洲欧美日韩综合一区在线观看 | 91精品国产品国语在线不卡 | 久色乳综合思思在线视频 | 爆乳3把你榨干哦OVA在线观看 | 日韩毛片AV无码免费一区二区三区 | 一级欧美一级日韩片老司机99 | 久久久精品国产亚洲AV无码 | 国内精品久久久久久久小说 | 国产成+人欧美+综合在线观看 | 国产二级一片内射视频插放 | 国产AV一区二区三区 |