亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产AV无码专区亚洲A∨毛片,欧美人与性囗牲恔配视频0,精品国产乱子久久久久
Rabbit Anti-VAV3/Cy5 Conjugated antibody (bs-4286R-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-4286R-Cy5
英文名稱 Rabbit Anti-VAV3/Cy5 Conjugated antibody
中文名稱 Cy5標(biāo)記的鳥嘌呤核苷酸交換因子VAV3抗體
別    名 Guanine nucleotide exchange factor VAV3; Protein vav 3; Protein vav3; VAV 3; Vav 3 guanine nucleotide exchange factor; VAV 3 oncogene; VAV 3 protein; VAV-3; Vav3; VAV3 oncogene; VAV3 protein; VAV3_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  G蛋白偶聯(lián)受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 97kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human VAV3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The Vav family of Rho guanine nucleotide exchange factors (GEFs) orchestrate signaling events following lymphocyte antigen receptor activation. Vav3, like Vav (also known as Vav1 or p95Vav), undergoes tyrosine phosphorylation downstream of T cell receptor cross-linkage, and subsequently interacts with 2 adaptor molecules, SLP76 and 3BP2. Following these events, however, the paths of Vav and Vav3 diverge; Vav affects IL-2 promotor activity, while Vav3 impacts gene transcription linked to serum response element (SRE). Furthermore, Vav3 expression follows a cell cycle-dependent pattern, with transient upregulation occuring during mitosis. Encforced Vav3 expression leads to the appearance of multinucleate cells, implicating a role for Vav3 in the control of cytokinesis.

Function:
Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitement by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).

Subunit:
Interacts with the PH domain of APS. Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation.

Tissue Specificity:
Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable.

Post-translational modifications:
Phosphorylated. Phosphorylation can be mediated by ROS1. In osteoclasts, undergoes tyrosine phosphorylation in response to CSF1 (By similarity).

Similarity:
Contains 1 CH (calponin-homology) domain.
Contains 1 DH (DBL-homology) domain.
Contains 1 PH domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 SH2 domain.
Contains 2 SH3 domains.

Database links:

Entrez Gene: 10451 Human

Entrez Gene: 57257 Mouse

Omim: 605541 Human

SwissProt: Q9UKW4 Human

SwissProt: Q9R0C8 Mouse

Unigene: 267659 Human

Unigene: 282257 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

癌基因Vav3屬于Vav家族癌基因蛋白類,它含有多個(gè)功能單位,主要通過信號(hào)傳導(dǎo),參與了腫瘤的發(fā)生發(fā)展過程,包括細(xì)胞骨架重組、鈣離子內(nèi)流、調(diào)控基因轉(zhuǎn)錄、對(duì)細(xì)胞可塑性和遷移的調(diào)節(jié),對(duì)維持細(xì)胞形態(tài),細(xì)胞的粘附,血管的生成,免疫細(xì)胞的調(diào)節(jié),細(xì)胞的分化等發(fā)揮著作用。Vav3表達(dá)的失調(diào)與腫瘤的發(fā)生有一定的關(guān)聯(lián),并有著原癌基因的活性。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
无套内射在线无码播放 | 97人人模人人爽人人 | 久久久久久久久久久免费精品国产 | 黑人巨大精品欧美一区二区 | 性高湖久久久久久久久 | 色青青草原桃花久久综合 | 午夜dv内射一区二区 | 最近高清中文字幕无吗免费看 | 亚洲国产中文字幕在线观看 | 国产成人一区二区啪在线观看 | 日韩成人精品视频免费专区 | 综合欧美亚洲日本一区 | 精品久久久久久无码人妻热蜜芽 | 国产精品久久国产三级国电话系列 | 中文字幕欧美另类精品亚洲 | 少妇人妻一级A毛片无码 | 日本中文字幕有码在线视频 | 免费在线观看的毛片 | 公与淑婷厨房猛烈进出视频韩国 | 免费va国产高清大片在线 | 久久黄无码国内久久精品 | 久久久精品国产亚洲AV综合 | 久久精品九九亚洲精品 | 被伴郎的内捧猛烈进出H视频 | 情趣白丝女仆下部被揉小说合集 | 国产刺激高潮免费不卡 | 日本三级带日本三级带黄国产 | 91在线一区二区 | 欧亚成年男女深夜百度网盘 | 精品人妻aV中文字幕乱码 | 综合一区无套内射中文字幕 | 重口SM一区二区三区视频 | 波多野结衣的AV一区二区三区 | 四虎影视一区二区精品 | 欧美一区二区三区播放 | 91网站在线免费观看 | 久久成人18免费网站 | 91热成人精品国产免费 | 校花系列辣h文黑人宫交 | 18禁黄网站禁片免费观看久久 | 亚洲日韩国产精品乱-久 |