亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
美女祼体无遮挡又污又黄又爽视频在线看,亚洲国产另类久久久精品,视频在线观看一区
Rabbit Anti-VAV3/Cy7 Conjugated antibody (bs-4286R-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-4286R-Cy7
英文名稱 Rabbit Anti-VAV3/Cy7 Conjugated antibody
中文名稱 Cy7標(biāo)記的鳥嘌呤核苷酸交換因子VAV3抗體
別    名 Guanine nucleotide exchange factor VAV3; Protein vav 3; Protein vav3; VAV 3; Vav 3 guanine nucleotide exchange factor; VAV 3 oncogene; VAV 3 protein; VAV-3; Vav3; VAV3 oncogene; VAV3 protein; VAV3_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  G蛋白偶聯(lián)受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 97kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human VAV3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The Vav family of Rho guanine nucleotide exchange factors (GEFs) orchestrate signaling events following lymphocyte antigen receptor activation. Vav3, like Vav (also known as Vav1 or p95Vav), undergoes tyrosine phosphorylation downstream of T cell receptor cross-linkage, and subsequently interacts with 2 adaptor molecules, SLP76 and 3BP2. Following these events, however, the paths of Vav and Vav3 diverge; Vav affects IL-2 promotor activity, while Vav3 impacts gene transcription linked to serum response element (SRE). Furthermore, Vav3 expression follows a cell cycle-dependent pattern, with transient upregulation occuring during mitosis. Encforced Vav3 expression leads to the appearance of multinucleate cells, implicating a role for Vav3 in the control of cytokinesis.

Function:
Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitement by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).

Subunit:
Interacts with the PH domain of APS. Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation.

Tissue Specificity:
Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable.

Post-translational modifications:
Phosphorylated. Phosphorylation can be mediated by ROS1. In osteoclasts, undergoes tyrosine phosphorylation in response to CSF1 (By similarity).

Similarity:
Contains 1 CH (calponin-homology) domain.
Contains 1 DH (DBL-homology) domain.
Contains 1 PH domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 SH2 domain.
Contains 2 SH3 domains.

Database links:

Entrez Gene: 10451 Human

Entrez Gene: 57257 Mouse

Omim: 605541 Human

SwissProt: Q9UKW4 Human

SwissProt: Q9R0C8 Mouse

Unigene: 267659 Human

Unigene: 282257 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

癌基因Vav3屬于Vav家族癌基因蛋白類,它含有多個(gè)功能單位,主要通過信號(hào)傳導(dǎo),參與了腫瘤的發(fā)生發(fā)展過程,包括細(xì)胞骨架重組、鈣離子內(nèi)流、調(diào)控基因轉(zhuǎn)錄、對(duì)細(xì)胞可塑性和遷移的調(diào)節(jié),對(duì)維持細(xì)胞形態(tài),細(xì)胞的粘附,血管的生成,免疫細(xì)胞的調(diào)節(jié),細(xì)胞的分化等發(fā)揮著作用。Vav3表達(dá)的失調(diào)與腫瘤的發(fā)生有一定的關(guān)聯(lián),并有著原癌基因的活性。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
澳门一级特黄录像免费播黄 | 无码人妻免费—区二区三 | 99国产一区二区三区亚洲一区影院午夜 | 欧美影视一区二区三区 | 国产精品毛片a∨一区二区三区 | 内射人妻精品丨色AV无码 | 欧美色精品视频在线观看九 | 亚洲AV日韩AV无码AV一区二区三区 | 亚洲高清成人AV电影网站 | 欧洲性开放大片免费观看视频 | 白丝乳交内射一二三区 | 视频完整版午夜达达兔影院 | 国精品午夜福利视频不卡麻豆 | 人人人人爽人人人人爱 | 丰满少妇被猛男猛烈进入久久 | 亚洲熟妇av一区二区三区色堂 | 永久免费观看国产裸体美女 | 娇妻在客厅被朋友玩得呻吟漫画 | 适合晚上看的东西免费软件 | 丰满少妇被猛烈进入毛片 | 日韩欧美一中文字慕2O22 | 久久久高清免费视频 | 色天天爱天天狠天天透 | 久久九九日本韩国精品 | 少妇人妻一级A毛片无码 | 动漫美女h片黄动漫在线观看 | 一本到无码高清手机字幕在线播放 | 一级特黄大片欧美久久久久久 | 免费无码一区二区三区蜜桃大 | 国产一级精品免费看高清99 | 黑白配黑粗硬大疯狂乱叫 | 亚洲精品123区在线观看 | 国产www在线观看 | 亚洲精品永久在线观看 | 欧美肥胖老太vidio在线视频 | 久久中文字幕亚洲一区二区 | 国产二级一片内射视频播放 | 亚洲二区在线视频 | 中文国产高清综合乱色视频在线播放 | 久久综合经典国产二区无码 | JAPANXXXⅩ日本人妻HD |