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Rabbit Anti-PHLP/Gold Conjugated antibody (bs-5812R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-5812R-Gold
英文名稱 Rabbit Anti-PHLP/Gold Conjugated antibody
中文名稱 膠體金標記的腫瘤抑制基因PHLPP抗體
別    名 hSCOP; PH domain and leucine rich repeat protein phosphatase; PH domain leucine rich repeat containing protein phosphatase; PH domain leucine rich repeat protein phosphatase; PH domain leucine-rich repeat protein phosphatase; PH domain leucine-rich repeat-containing protein phosphatase 1; PH domain leucine-rich repeat-containing protein phosphatase; PH domain-containing family E member 1; PHLP1_HUMAN; PHLPP1; Pleckstrin homology domain containing family E protein 1; Pleckstrin homology domain-containing family E member 1; Pleckstrin homology domain-containing family E protein 1; PLEKHE 1 protein; SCN circadian oscillatory protein; SCOP; SUPRACHIASMATIC NUCLEUS CIRCADIAN OSCILLATORY PROTEIN; Suprachiasmatic nucleus circadian protein.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 腫瘤  細胞生物  免疫學  信號轉(zhuǎn)導(dǎo)  細胞凋亡  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, Chicken, Pig, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PHLP
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. May act as a negative regulator of K-Ras signaling in membrane rafts.

Subunit:
Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.

Similarity:
Belongs to the phosducin family.

Database links:

Entrez Gene: 5082 Human

Entrez Gene: 67466 Mouse

Entrez Gene: 64013 Rat

Omim: 604421 Human

SwissProt: Q13371 Human

SwissProt: Q9DBX2 Mouse

SwissProt: Q63737 Rat

Unigene: 271749 Human

Unigene: 620774 Human

Unigene: 30709 Mouse

Unigene: 51153 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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