亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
欧美高清videosex,亚洲免费视频在线
Rabbit Anti-EBP50/APC Conjugated antibody (bs-5883R-APC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-5883R-APC
英文名稱 Rabbit Anti-EBP50/APC Conjugated antibody
中文名稱 APC標(biāo)記的細(xì)胞骨架連接質(zhì)膜蛋白抗體
別    名 EBP 50; EBP50; Ezrin radixin moesin binding phosphoprotein 50; Ezrin-radixin-moesin-binding phosphoprotein 50; Na(+)/H(+) exchange regulatory cofactor NHE RF; Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Na+/H+ exchange regulatory co factor; NHERF 1; NHERF; NHERF-1; NHERF1; NHRF1_HUMAN; NPHLOP2; Regulatory cofactor of Na(+)/H(+) exchanger; SLC9A3R1; Sodium hydrogen exchanger regulatory factor 1; Sodium-hydrogen exchanger regulatory factor 1; Sodium/hydrogen exchanger regulatory factor 1; Solute carrier family 9 (sodium/hydrogen exchanger) member 3 regulator 1; Solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1; Solute carrier family 9 isoform 3 regulatory factor 1; Solute carrier family 9 isoform A3 regulatory factor 1; Solute carrier family 9 member 3 regulator 1.   
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  結(jié)合蛋白  細(xì)胞類型標(biāo)志物  血管內(nèi)皮細(xì)胞  細(xì)胞骨架  細(xì)胞外基質(zhì)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EBP50/SLC9A3R1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Interacts with MCC.

Function:
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules.

Subunit:
Homodimer, and heterodimer with SLC9A3R2. Binds the N-termini of EZR, RDX and MSN. Binds the C-termini of PDGFRA, PDGFRB, ADRB2, NOS2 and CFTR. Binds ARHGAP17, EPI64, GNB2L1, OPRK1, GNAQ, CTNNB1 and PLCB3. Binds PDZK1 (By similarity). Interacts with CLCN3. Binds the C-terminus of PAG1. In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation. Forms a complex with CFTR and SLC4A7. Forms a complex with SLC4A7 and ATP6V1B1. Interacts with TRPC4 (via the PDZ-binding domain). Directly interacts with HTR4. Interacts (via the PDZ 1 domain) with PODXL (via the C-terminal PDZ-binding motif DTHL); interaction is not detected in glomerular epithelium cells. Interacts (via the PDZ 1 domain) with PODXL (via the C-terminal PDZ-binding motif DTHL); the interaction take place early in the secretory pathway and is necessary for its apical membrane sorting. Interacts with MCC. Interacts with SLC34A1.

Subcellular Location:
Cytoplasm. Apical cell membrane. Endomembrane system; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Note=Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner. Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Found in microvilli, ruffling membrane and filopodia of HeLa cells. Present in lipid rafts of T-cells.

Tissue Specificity:
Detected in liver, kidney, pancreas, prostate, spleen, small intestine and placenta, in particular in the syncytiotrophoblast.

Post-translational modifications:
Phosphorylated on serine residues.

DISEASE:
Nephrolithiasis/osteoporosis, hypophosphatemic, 2 (NPHLOP2) [MIM:612287]: A disease characterized by decreased renal phosphate absorption, renal phosphate wasting, hypophosphatemia, hyperphosphaturia, hypercalciuria, nephrolithiasis and osteoporosis. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Contains 2 PDZ (DHR) domains.

Database links:

Entrez Gene: 505242 Cow

Entrez Gene: 9368 Human

Entrez Gene: 26941 Mouse

Entrez Gene: 100009196 Rabbit

Entrez Gene: 59114 Rat

Omim: 604990 Human

SwissProt: Q3SZK8 Cow

SwissProt: O14745 Human

SwissProt: P70441 Mouse

SwissProt: Q28619 Rabbit

SwissProt: Q9JJ19 Rat

Unigene: 724482 Human

Unigene: 728760 Human

Unigene: 27842 Mouse

Unigene: 35142 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
好看的国产精彩视频 | 亚日韩一二三区视频免费看 | 免费A级毛片—亚洲一区二区久久69 | 内射干少妇亚洲69XXX | 一本色道久久88综合日韩精品 | 日本一区二区三区在线视频观看免费 | 任你躁在线精品免费 | 两根硕大一起挤进小紧H共妻 | 久久国产免费观看精品1 | 内射人妻精品丨色AV无码 | 被三个男人绑着躁我好爽 | 真实国产精品视频国产网 | 久久成人国产精品一区二区 | 乱欧人与牲口杂交暴力狂 | 娇喘嗯嗯~轻点啊视频福利 | 日韩特黄特色大片免费视频 | 国产女人乱人伦精品一区二区 | 一本到无码高清手机字幕在线播放 | 日本精品一区二区三区高清 | 校花系列辣h文黑人宫交 | 高潮毛片无遮挡高清免费视频 | 91国内揄拍国内精品对白不卡 | 91麻豆精品一二三区在线 | 国产在线拍揄自揄拍无码APP | 国产精品乱码一区二区三区 | 久久久久久精品免费免费WE | 伊人久久大香线蕉亚洲五月天 | 精品无码国产AV一区二区三区 | 亚洲国产精品成人综合色GIF | 日韩亚洲人成在线 | 日韩中文字幕在线看视频免费 | 国产精品午夜免费观看网站 | 亚洲AV无码国产精品久久不卡 | 午夜福利一区二区三区高清视频 | 噜噜色青草久久丁香伊人 | 国产精品久久久久久影视 | 91免费精品国自产拍在线不卡 | 青青青免费高清在线观看一区二区 | 黄网站动漫免费永久在线观看网站入口 | 日韩精品区一区二区三VR | 在线视频一区二区三区四区 |