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Rabbit Anti-SnoN/BF350 Conjugated antibody (bs-5945R-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-5945R-BF350
英文名稱 Rabbit Anti-SnoN/BF350 Conjugated antibody
中文名稱 BF350標記的Smad核轉(zhuǎn)錄共抑制因子抗體
別    名 SKI like; Ski related oncogene; Ski related protein; SKIL; SnoA; SNO; SnoA; SnoI; SnoN; SKIL_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細胞生物  免疫學(xué)  染色質(zhì)和核信號  信號轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 77kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SnoN
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
SnoN may have a regulatory role in cell division or differentiation in response to extracellular signals. SnoN acts as a positive mediator of TGF beta induced transcription and cell cycle arrest in lung epithelial cells. The ability of SnoN to repress the growth inhibitory function of the Smad proteins is required for their transforming activity.

Function:
May have regulatory role in cell division or differentiation in response to extracellular signals.

Subunit:
Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1.

Tissue Specificity:
Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle.

Similarity:
Belongs to the SKI family.

Database links:
UniProtKB/Swiss-Prot: P12757.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Smad核轉(zhuǎn)錄共抑制因子(SnoN)是一種拮抗劑,可嚴格調(diào)控轉(zhuǎn)化生長因子-β1/smad(TGF-β1/Smad)信號的活性,從而保證在正常的生理條件下TGF-β1/smad信號輸出的穩(wěn)定性。
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