亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
精品久久BBBBB精品人妻,亚洲AV无码乱码在线观看侵犯
Rabbit Anti-RAGE/Cy3 Conjugated antibody (bs-4999R-Cy3)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-4999R-Cy3
英文名稱 Rabbit Anti-RAGE/Cy3 Conjugated antibody
中文名稱 Cy3標(biāo)記的晚期糖基化終末產(chǎn)物特異性受體抗體
別    名 Advanced glycosylation end product specific receptor; Advanced glycosylation end product-specific receptor; AGER; EC 2.7.11.22; LE 9211 A antigen;LE-9211-A antigen; MGC22357; MOK; RAGE 1; RAGE1; MOK protein kinase; Receptor for advanced glycation endproducts;Renal tumor antigen 1; Renal tumor antigen; Renal cell carcinoma antigen (MOK protein kinase); Renal tumor antigen 1; RAGE_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  神經(jīng)生物學(xué)  生長(zhǎng)因子和激素  糖尿病  內(nèi)分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human AGER Isoform 1, not for Isoform 2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Advanced glycosylation end product-specific receptor (AGER; RAGE) is a member of the immunoglobulin superfamily of cell surface molecules that binds molecules that have been irreversibly modified by non-enzymatic glycation and oxidation, and are know as advanced glycation end products (AGEs). It is expressed by endothelium, mononuclear phagocytes, neurons and smooth muscle cells. Whereas RAGE is present at high levels during development, especially in the central nervous system, its levels decline during maturity.The increased expression of RAGE is associated with several pathological states, such as diabetic vasculopathy, neuropathy, retinopathy and other disorders, including Alzheimer's disease and immune/inflammatory reactions of the vessel walls. In diabetic tissues, the production of RAGE is due to the overproduction of AGEs that eventually overwhelm the protective properties of RAGE. This results in oxidative stress and endothelial cell dysfunction that leads to vascular disease in diabetics. In the brain, RAGE also binds amyloid beta (Ab). Because Ab is overproduced in neurons and vessels in the brains of Alzheimer disease, this leads to the hyperstimulation of RAGE. The RAGE-Ab interaction is thought to result in oxidative stress leading to neuronal degeneration.

Function:
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.

Subunit:
Interacts with S100B, S100A1 and APP. Interacts with S100A12.

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Tissue Specificity:
Endothelial cells and cardiomyocytes.

Similarity:
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Database links:

Entrez Gene: 177 Human

Entrez Gene: 11596 Mouse

Entrez Gene: 81722 Rat

Omim: 600214 Human

SwissProt: Q15109 Human

SwissProt: Q62151 Mouse

SwissProt: Q63495 Rat

Unigene: 534342 Human

Unigene: 3383 Mouse

Unigene: 9829 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
亚欧洲乱码视频一二三区 | 免费又黄又裸乳的gif动态图 | 亚洲AV无码久久无遮挡 | 久久成人国产精品免费 | 寡妇高潮一级毛片免费看 | 最新高清无码专区 | 国产在线码观看超清无码视频 | 国产精品久久久久久久久99热 | 精品国产污污免费网站入口 | 99久久这里只精品国产免费 | 亚洲精品天天影视综合网 | YW尤物爆乳网站点击进入 | 日韩视频在线精品视频免费观看 | 亚洲AV午夜福利无码精品一区 | 国产精品久久一区二区三区蜜桃 | 又硬又粗又大一区二区三区视频 | 狂野欧美激情性XXXX在线观看 | 日出水了特别黄的视频 | 国产精品毛片a∨一区二区三区 | 亚洲专区无码天堂中文字幕 | 国产一区内射最近更新 | 少妇高潮惨叫久久久久69 | AV色欲无码人妻中文字幕 | **女人一级毛片免费视频观看 | 向日葵视频APP秋葵榴莲网站 | 亚洲国产精品剧情污污 | 午夜婷婷一夜七次郎 | 国产亚洲欧美日韩综合综合二区 | 亚洲国产精品特色大片观看完整版 | 亚洲999精品视频免费观看 | 国内毛片毛片毛片毛片毛片毛片毛片毛片毛片毛片毛片毛片 | 精品综合久久久久久88 | 豪妇荡乳1一5潘金莲2乳 | 亚洲一区二区三区高清AV | 插B内射18免费视频 内射无套在线观看高清完整免费 | 无码乱码精品少妇一级内射 | 99国产精品一区二区三区四区五区 | 精品无码国产AV一区二区性色 | 精品国产乱码久久久久久浪潮 | 中文字幕在线成人免费看 | 国产啪精品视频网免费 |