亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产寡妇婬乱A毛片视频,亚洲人AV永久一区二区三区久久,久久久99精品免费观看
Rabbit Anti-RAGE/Cy5.5 Conjugated antibody (bs-4999R-Cy5.5)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-4999R-Cy5.5
英文名稱 Rabbit Anti-RAGE/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標(biāo)記的晚期糖基化終末產(chǎn)物特異性受體抗體
別    名 Advanced glycosylation end product specific receptor; Advanced glycosylation end product-specific receptor; AGER; EC 2.7.11.22; LE 9211 A antigen;LE-9211-A antigen; MGC22357; MOK; RAGE 1; RAGE1; MOK protein kinase; Receptor for advanced glycation endproducts;Renal tumor antigen 1; Renal tumor antigen; Renal cell carcinoma antigen (MOK protein kinase); Renal tumor antigen 1; RAGE_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  神經(jīng)生物學(xué)  生長(zhǎng)因子和激素  糖尿病  內(nèi)分泌病  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human AGER Isoform 1, not for Isoform 2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Advanced glycosylation end product-specific receptor (AGER; RAGE) is a member of the immunoglobulin superfamily of cell surface molecules that binds molecules that have been irreversibly modified by non-enzymatic glycation and oxidation, and are know as advanced glycation end products (AGEs). It is expressed by endothelium, mononuclear phagocytes, neurons and smooth muscle cells. Whereas RAGE is present at high levels during development, especially in the central nervous system, its levels decline during maturity.The increased expression of RAGE is associated with several pathological states, such as diabetic vasculopathy, neuropathy, retinopathy and other disorders, including Alzheimer's disease and immune/inflammatory reactions of the vessel walls. In diabetic tissues, the production of RAGE is due to the overproduction of AGEs that eventually overwhelm the protective properties of RAGE. This results in oxidative stress and endothelial cell dysfunction that leads to vascular disease in diabetics. In the brain, RAGE also binds amyloid beta (Ab). Because Ab is overproduced in neurons and vessels in the brains of Alzheimer disease, this leads to the hyperstimulation of RAGE. The RAGE-Ab interaction is thought to result in oxidative stress leading to neuronal degeneration.

Function:
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.

Subunit:
Interacts with S100B, S100A1 and APP. Interacts with S100A12.

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Tissue Specificity:
Endothelial cells and cardiomyocytes.

Similarity:
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Database links:

Entrez Gene: 177 Human

Entrez Gene: 11596 Mouse

Entrez Gene: 81722 Rat

Omim: 600214 Human

SwissProt: Q15109 Human

SwissProt: Q62151 Mouse

SwissProt: Q63495 Rat

Unigene: 534342 Human

Unigene: 3383 Mouse

Unigene: 9829 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
黑人啊灬啊灬啊灬快灬深 | √天堂资源地址在线官网 | 精品久久久久久亚洲中文字幕 | 国产综合无码一区二区色蜜蜜 | √新版天堂资源在线资源 | 国产精品无码不卡系列在线 | 欧美大屁股XXXX高跟欧美黑人 | 亚洲国产天堂久久综合网 | 丝袜自慰一区二区三区四区 | JVID亚洲精品无圣光图套 | 免费特黄一区二区三区视频一 | 国产精品毛片一级久久 | 免费被黄动漫网站在线无网观看 | 中文字幕秘 一区二区人妻 成人国产一区二区精品小说 | 欧美人妻AⅤ中文字幕 | 狠狠色色综合网站 | 一本久久综合亚洲鲁鲁五月天 | 成年女人色毛片免费 | 亚洲中文字幕aV女同在线 | 人妻中文字幕乱人伦在线 | WWW国产精品内射熟女 | 放荡的小峓子2中文字幕 | 最新国产精品好看的国产精品 | 精品国产乱码欠欠欠欠精品 | 欧美精品在欧美一区二区少妇 | 一级毛片免费视频网站 | 国产三级毛片视频 | 久久91综合国产91久久精品 | 国产三级视频在线播放线观看 | 国产主播福利一区二区 | 亚洲第一成年免费网站 | 小宝极品内射国产在线 | 国第一产在线精品亚洲区^& | 久久强奷乱码老熟女 | 无码不卡中文字幕一区二区三区 | 欧美一级特黄aaaaaa在线看首页 | 免费一区二区三区久久 | 国模白灵私拍[150P] | 夜夜躁狠狠躁日日躁2022 | 91福利国产在线观看网站 | 按摩媚药无码中文字幕 |